340855

Glutaraldeide

50 wt. % in H₂O

• Sinonimo/i: Dialdeide glutarica, Pentano-1,5-diale
• Formula condensata: OHC(CH₂)₃CHO
• Numero CAS: 111-30-8
• Peso molecolare: 100.12
• Beilstein: 605390
• Numero MDL: MFCD00007025
• Codice UNSPSC: 12352114
• ID PubChem: 24860868
• NACRES: NA.21

Proprietà

• Densità del vapore: 1.05 (vs air)
• Livello qualitativo: 200
• Tensione di vapore: 15 mmHg ( 20 °C)
• Forma fisica: liquid
• Concentrazione: 50 wt. % in H₂O
• tecniche: electron microscopy: suitable; immunoblotting: suitable; immunohistochemistry: suitable
• Colore: colorless
• Indice di rifrazione: n20/D 1.42
• Punto di fusione: -21 °C ((-6 °F))
• Solubilità: water: soluble
• Densità: 1.106 g/mL at 25 °C
• Compatibilità: suitable for microfluidics/nanofluidics
• applicazioni: cell analysis; genomic analysis; life science and biopharma; sample preparation
• Stringa SMILE: [H]C(CCCC([H])=O)=O
• InChI: 1S/C5H8O2/c6-4-2-1-3-5-7/h4-5H,1-3H2; SXRSQZLOMIGNAQ-UHFFFAOYSA-N

Descrizione

Descrizione generale

Glutaraldehyde (Glutaric dialdehyde, Pentane-1,5-dial) is an aliphatic dialdehyde that can be employed as an effective biochemical reagent for various purposes such as a protein crosslinker, enzyme immobilization in microscopy, histochemistry, and cytochemistry. It serves as an amine-reactive homobifunctional crosslinker and a cell fixative before SDS-PAGE, staining, or electron microscopy, making it suitable for a wide range of morphological studies.

Glutaraldehyde is capable of efficiently crosslinking amine and hydrazine derivatives to proteins and other amine-containing polymers. Notably, in certain reactions, biotin hydrazides have been directly coupled to nucleic acids using glutaraldehyde, presenting a potential utility in conjugating fluorescent hydrazides and hydroxylamines to DNA. In histology studies, Glutaraldehyde is also employed to preserve tissue sections and prepare them for closer examination.

Applicazioni

Cross-linking agent for gelatin, poly(vinyl alcohol), and polyheptapeptides.

Glutaraldehyde may be used in the following studies:

• To compose the fixative solution (Glutaraldehyde + Paraformaldehyde + NaPO₄) for use in high-resolution light microscopy and electron microscopy studies.
• To study the conjugation of goat anti-horseradish peroxidase with alkaline phosphatase by a reported method.
• To compose the primary fixative, which is employed to protect the deterioration of cytoplasmic features of yeast cells during permanganate fixation.

Caratteristiche e vantaggi

• Versatile and adaptable for wide variety of research applications
• Ready-made solution reduces the need for preparation time

Altre note

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Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS08,GHS05,GHS09
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H314,H317,H331,H334,H335,H410
• Consigli di prudenza: P273 - P280 - P301 + P312 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
• Classi di pericolo: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 2 - Eye Dam. 1 - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3
• Organi bersaglio: Respiratory system
• Rischi supp: EUH071
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3