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04471

Supelco

(R)-(+)-α-Lipoic acid

analytical standard

Sinonimo/i:

(R)-(+)-1,2-Dithiolane-3-pentanoic acid, (R)-6,8-Dithiooctanoic acid, (R)-6,8-Thioctic acid

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About This Item

Formula empirica (notazione di Hill):
C8H14O2S2
Numero CAS:
Peso molecolare:
206.33
Numero MDL:
Codice UNSPSC:
85151701
ID PubChem:
NACRES:
NA.24

Grado

analytical standard

Livello qualitativo

Saggio

≥98.0% (HPLC)

Attività ottica

[α]/D +115±5°, c = 1% in ethanol

Durata

limited shelf life, expiry date on the label

tecniche

HPLC: suitable
gas chromatography (GC): suitable

Punto di fusione

48-52 °C (lit.)

applicazioni

cleaning products
cosmetics
food and beverages
personal care

Formato

neat

Temperatura di conservazione

2-8°C

Stringa SMILE

OC(=O)CCCC[C@@H]1CCSS1

InChI

1S/C8H14O2S2/c9-8(10)4-2-1-3-7-5-6-11-12-7/h7H,1-6H2,(H,9,10)/t7-/m1/s1
AGBQKNBQESQNJD-SSDOTTSWSA-N

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Descrizione generale

α-Lipoic acid is an antioxidant which is generally present in plants, animals and many other microorganisms.

Applicazioni

α-Lipoic acid has been used as a reference standard for the analysis of α-lipoic acid in human plasma by high performance liquid chromatography coupled to electron capture detector (HPLC-ECD), in various food matrices and dietary supplements by HPLC combined with coulometric electrode array detector (CEAD) as well as electrospray ionization mass spectrometer (ESI-MS).
It may be used as a reference standard for the determination of α-lipoic acid in human urine by isocratic reversed-phase HPLC and in α-lipoic acid capsules by HPLC with chemiluminescence detection.

Confezionamento

Bottomless glass bottle. Contents are inside inserted fused cone.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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α-Lipoic Acid α-Lipoic Acid, CAS 1077-28-7 is an oxidized form with antioxidant properties. Reduces renal lipid peroxidation in rats with cisplatin n-induced nephrotoxicity.

Sigma-Aldrich

437692

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Sigma-Aldrich

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W Witt et al.
Journal of chromatography. B, Biomedical sciences and applications, 705(1), 127-131 (1998-03-14)
A new method for the quantitation of lipoic acid in plasma and tissues based on the selective precolumn derivatization of thiols with the fluorescent label monobromobimane is described. After extraction with diethyl ether, the dithiolane ring of lipoic acid is
Determination of free ?-lipoic acid in foodstuffs by HPLC coupled with CEAD and ESI-MS.
Durrani, et al.
Food Chemistry, 120(4), 1143-1148 (2010)
Determination of lipoic acid in human plasma by HPLC-ECD using liquid-liquid and solid-phase extraction: Method development, validation and optimization of experimental parameters.
Khan, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 878(28), 2782-2788 (2010)
Determination of lipoic acid by flow-injection and high-performance liquid chromatography with chemiluminescence detection.
Wolyniec, et al.
Talanta, 96(2), 223-229 (2012)
High-performance liquid chromatographic assay for $\alpha$-lipoic acid and five of its metabolites in human plasma and urine.
Teichert, et al.
Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences, 769(2), 269-281 (2002)

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