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SCT068

Sigma-Aldrich

BioTracker DUAL dUTPase Live Cell reporter

Live cell probe for activity of cellular enzyme deoxyuridine triphosphatase(dUTPase) involved in deactivation of damaged nucleotides. The probe acts as a luciferase luminescencereporter of dUPTase.

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About This Item

Codice UNSPSC:
12352207
NACRES:
NA.47

Stato

lyophilized

tecniche

activity assay: suitable

Metodo di rivelazione

chemiluminescent

Descrizione generale

Nucleotide surveillance enzymes play important roles inhuman health, by monitoring damaged monomers in the nucleotide pooland deactivating them before they are incorporated into chromosomalDNA or disrupt nucleotide metabolism. Deamination ofcytosine, leading to uracil in DNA and in the nucleotide pool, can bedeleterious, causing DNA damage. The enzyme deoxyuridine triphosphatase(dUTPase) is the sole enzyme that cleanses the nucleotide pool of deaminated cytosine. Measuring the activity of this enzyme is importantboth in basic research and in clinical applications involving thispathway.The BioTracker DUAL dUTPase live cell probe is a luminescence probe that specifically reports on dUTPase activity in real time. The probe is a chimera of dUTP and ATP. dUTPase enzyme accepts the DUAL probe as an efficient substrate and upon hydrolysis releases ATP, which is detected sensitively by luciferase luminescence.Note: Luceferin and luciferase enzyme are needed to detect ATP released by hydrolysis, but are not included in this product. Spectral Properties:Luminescence intensity.Research Category:Live Cell Dye

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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