MABN349

Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1

clone 1B12.1, 0.5 mg/mL, from mouse

• Sinonimo/i: Synaptotagmin-12, Synaptotagmin XII, SytXII, Synaptotagmin-12 (SYT12)
• Codice UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Livello qualitativo: 100
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 1B12.1, monoclonal
• Reattività contro le specie: human, rat
• Concentrazione: 0.5 mg/mL
• tecniche: western blot: suitable
• Isotipo: IgG1κ
• N° accesso NCBI: NP_001171351
• N° accesso UniProt: Q8IV01
• Condizioni di spedizione: wet ice
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... SYT12(91683)

Descrizione

Descrizione generale

Synaptotagmin-12 (SYT12) , also known as Synaptotagmin-12, Synaptotagmin XII, SytXII, and encoded by the gene SYT12, is an important protein involved in calcium dependent exocytosis of secretory vesicles through calcium and phospholipid binding to the C2 domain and Synaptotagmin-12 may serve as calcium sensors in the process of vesicular trafficking and exocytosis. Synaptotagmin-12 is a synaptic vesicle phosophoprotein that modulates spontaneous neurotransmitter release, but unlike other family members Synaptotagmin-12 differs from classical synaptotagmins in that it does not bind Ca(2+). In synaptic vesicles, synaptotagmin-12 forms a complex with synaptotagmin-1 that prevents synaptotagmin-1 from interacting with SNARE complexes. Synaptotagmin-12 also is an abundant synaptic vesicle protein that is important in LTP transmission. For instance, its phosphorylation by cAMP Protein Kinase is necessary for hippocampal mossy fiber LTP.

Immunogeno

Epitope: Cytoplasmic domain

GST-tagged recombinant protein corresponding to the cytoplasmic domain of human Synaptotagmin-12 (SYT12).

Applicazioni

Research Category
Neuroscience

Research Sub Category
Developmental Signaling

This Anti-Synaptotagmin-12 Antibody (SYT12), clone 1B12.1 is validated for use in Western Blotting for the detection of Synaptotagmin-12 (SYT12).

Qualità

Evaluated by Western Blotting in rat brain tissue lysate.

Western Blotting Analysis: 1.0 µg/mL of this antibody detected Synaptotagmin-12 (SYT12) in 200 µg of rat brain tissue lysate.

Descrizione del bersaglio

~ 47 kDa observed

Stato fisico

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stoccaggio e stabilità

Stable for 1 year at 2-8°C from date of receipt.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1