524718

Phosphodiesterase Inhibitor Set I

The Phosphodiesterase Inhibitor Set I controls the activity of Phosphodiesterase. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• Sinonimo/i: PDE Inhibitor Set
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Forma fisica: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Condizioni di spedizione: ambient
• Temperatura di conservazione: 2-8°C

Descrizione

Descrizione generale

A convenient set of inhibitors that are selective for PDE types I, III, IV, and V. Contains 10 mg of 8-Methoxymethyl-3-isobutyl-1-methylxanthine (Cat. No. 454202), a Ca²⁺/CaM-dependent PDE (PDE I) inhibitor; 1 mg of 4-{[3′,4′-(Methylenedioxy)benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), a cGMP-specific PDE (PDE V) inhibitor; 5 mg of Rolipram (Cat. No. 557330), a cAMP-specific PDE (PDE IV) inhibitor; and 10 mg of Trequinsin, Hydrochloride (Cat. No. 382425), a cGMP-inhibited PDE (PDE III) inhibitor. Supplied with data sheet.

Phosphodiesterases (PDEs) play an important role in the regulation of cAMP and cGMP levels in the cell. At least five PDE isozymes have been characterized that are differentially expressed and regulated in different cell types: Ca²⁺-calmodulin-dependent (PDE I); cGMP-stimulated (PDE II); cGMP-inhibited (PDE III); cAMP-specific (PDE IV); cGMP-specific (PDE V). These isozymes exhibit significant homology in their catalytic domain. The cyclic nucleotides are important regulators of many different cellular processes. They are involved in inflammation, asthma, and cardiovascular complications. Hence, specific inhibitors of the PDE isozymes have a potential for use as therapeutic agents. The Phosphodiesterase Inhibitor Set I contains the following inhibitors that are selective for PDE types l, III, IV, and V:



• 8-Methoxymethyl-3-isobutyl-1-methylxanthine(8-Methoxymethyl-IBMX) (Cat. No. 454202), 10 mg

• 4-{[3′,4′-(Methylenedioxy) benzyl]amino}-6-methoxyquinazoline (Cat. No. 475250), 1 mg

• Rolipram (Cat. No. 557330), 5 mg

• Trequinsin, Hydrochloride (Cat. No. 382425), 10 mg

Azioni biochim/fisiol

Primary Target
PDE I, PDE III, PDE IV, PDE V

Attenzione

Toxicity: Multiple Toxicity Values, refer to MSDS (O)

Ricostituzione

Following reconstitution of each inhibitor, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Altre note

See properties table for specific solvent and recommended stock concentration.

Takase, Y., et al. 1994. J. Med. Chem.37, 2106.
Underwood, D.C., et al. 1994. J. Pharmacol. Exp. Ther.270, 250.
Wells, J.N. and Miller, J.R. 1988. Methods Enzymol.159, 489.
Ruppert, D. and Weithmann, K.U. 1982. Life Sciences31, 2037.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids