239805

Cyclopiazonic Acid, Penicillium cyclopium

A cell-permeable, reversible inhibitor of sarcoplasmic reticulum Ca²⁺-ATPase that releases Ca²⁺ from the same intracellular pools as Thapsigargin.

• Sinonimo/i: Cyclopiazonic Acid, Penicillium cyclopium, CPA
• Formula empirica (notazione di Hill): C₂₀H₂₀N₂O₃
• Numero CAS: 18172-33-3
• Peso molecolare: 336.38
• Numero MDL: MFCD00167445
• Codice UNSPSC: 12352200

Proprietà

• Livello qualitativo: 100
• Saggio: ≥97% (TLC)
• Stato: solid
• Produttore/marchio commerciale: Calbiochem^®
• Condizioni di stoccaggio: OK to freeze
• Colore: off-white
• Solubilità: DMSO: 1 mg/mL; chloroform: 10 mg/mL
• Condizioni di spedizione: ambient
• Temperatura di conservazione: −20°C
• InChI: 1S/C20H20N2O3/c1-9(23)14-18(24)17-16-11-8-21-13-6-4-5-10(15(11)13)7-12(16)20(2,3)22(17)19(14)25/h4-6,8,12,16-17,21,25H,7H2,1-3H3/t12-,16+,17+/m1/s1; RLOAZVAJNNPPDI-DQYPLSBCSA-N

Descrizione

Descrizione generale

A cell-permeable, reversible inhibitor of endoplasmic reticulum Ca²⁺-ATPase that releases Ca²⁺ from the same intracellular pools as thapsigargin. Mobilizes Ca²⁺ without increasing the levels of Ins(1,4,5)P₃. Also known to inhibit sarcoplasmic reticular Ca²⁺-ATPase that is distinct from actomyosin ATPase. Bay K 8644 (Cat. No. 196878) can reverse the inhibitory effect of cyclopiazonic acid on the refilling of Ca²⁺ pools that have been depleted by repetitive stimulation with acetylcholine.

Azioni biochim/fisiol

Cell permeable: yes

Primary Target
Ca²⁺ uptake in cultured arterial musclue cells

Product does not compete with ATP.

Reversible: yes

Target IC₅₀: 560 nM inhibiting Ca2+ uptake in cultured arterial smooth muscle cells

Attenzione

Toxicity: Toxic (F)

Ricostituzione

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Altre note

Badaoui, A., et al. 1995. J. Mol. Cell. Cardiol. 27, 2495.
Elmoselli, A.B., et al. 1995. Mol. Cell. Biochem. 151, 149.
Schaefer, A., et al. 1994. J. Biol. Chem.269, 8786.
Demaurex, N., et al. 1992. J. Biol. Chem.267, 2318.
Low, A.M., et al. 1992. Am. J. Physiol.262, H31.
Kurebayashi, N., and Ogawa, Y. 1991. J. Muscle Res. Cell Motil.12, 355.
Mason, M.J., et al. 1991. J. Biol. Chem.266, 20856.

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Pittogrammi: GHS06
• Avvertenze: Danger
• Indicazioni di pericolo: H300
• Consigli di prudenza: P264 - P270 - P301 + P310 - P405 - P501
• Classi di pericolo: Acute Tox. 2 Oral
• Codice della classe di stoccaggio: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable