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Merck
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Documenti fondamentali

203389

Sigma-Aldrich

Blebbistatin, Racemic

≥97% (HPLC), liquid, Myosin II inhibitor, Calbiochem®

Sinonimo/i:

InSolutionBlebbistatin, Racemic

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5 MG
CHF 270.00

CHF 270.00

Spedizione prevista il15 aprile 2025

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5 MG
CHF 270.00

About This Item

Formula empirica (notazione di Hill):
C18H16N2O2
Peso molecolare:
292.33
Codice UNSPSC:
12352200
NACRES:
NA.77

CHF 270.00

Spedizione prevista il15 aprile 2025

Nome del prodotto

Blebbistatin, Racemic, InSolution, ≥97%, 50 mM in 90% DMSO, reversible inhibitor of nonmuscle myosin II

Livello qualitativo

100

Saggio

≥97% (HPLC)

Stato

liquid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
desiccated (hygroscopic)
protect from light

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Descrizione generale

A cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.

Azioni biochim/fisiol

Cell permeable: yes
Primary Target
ATPase
Product does not compete with ATP.
Reversible: yes
Target IC50: <100 µM inhibiting the ATPase and gliding motility of human platelets

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Harmful & Carcinogenic / Teratogenic (E)

Stato fisico

A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203390) in 90% DMSO.

Ricostituzione

Following initial thaw, aliquot and freeze (-20°C).

Altre note

Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA102, 1472.
Kovacs, M., et al. 2004. J. Biol. Chem.279, 35557.
Straight, A.F., et al. 2003. Science299, 1743.
Cheung, A., et al. 2001. Mol. Biol. Cell Suppl.12, 271a.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Punto d’infiammabilità (°C)

87 °C - closed cup - (Dimethylsulfoxide)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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