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189826

Sigma-Aldrich

5-Aza-2′-Deoxycytidine

≥98% (HPLC), liquid, DNA methyltransferase inhibitor, Calbiochem

Sinonimo/i:

InSolution 5-Aza-2′-Deoxycytidine, Decitabine

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10 MG
CHF 245.00

CHF 245.00

Spedizione prevista il29 maggio 2025

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10 MG
CHF 245.00

About This Item

Formula empirica (notazione di Hill):
C8H12N4O4
Numero CAS:
2353-33-5
Peso molecolare:
228.21
Numero MDL:
MFCD00043011
Codice UNSPSC:
12352200
NACRES:
NA.77

CHF 245.00

Spedizione prevista il29 maggio 2025

Nome del prodotto

5-Aza-2′-Deoxycytidine, InSolution, ≥98%, DNA methyltransferase inhibitor

Livello qualitativo

100

Saggio

≥98% (HPLC)

Stato

liquid

Produttore/marchio commerciale

Calbiochem®

Condizioni di stoccaggio

OK to freeze
desiccated (hygroscopic)
protect from light

Condizioni di spedizione

ambient

Temperatura di conservazione

−20°C

Stringa SMILE

N2(C=NC(=N)NC2=O)C1OC(C(C1)O)CO

InChI

1S/C8H12N4O4/c9-7-10-3-12(8(15)11-7)6-1-4(14)5(2-13)16-6/h3-6,13-14H,1-2H2,(H2,9,11,15)
XAUDJQYHKZQPEU-UHFFFAOYSA-N

Descrizione generale

A cytosine analog that acts as a DNA methyltransferase inhibitor. Restores caspase-8 and caspase-10 mRNA and protein expression as well as TRAIL (Tumor necrosis factor-Related Apoptosis Inducing Ligand) sensitivity in TRAIL-resistant cell lines. Also enhances apoptosis induced by HDAC (Histone Deacetylase) inhibitors. The solid form of this compound (Cat. No. 189825) is also available.

Confezionamento

Packaged under inert gas

Attenzione

Toxicity: Regulatory Review (Z)

Stato fisico

A 100 mM (10 mg/438 µl) solution of 5-Aza-2ʹ-Deoxycytidine (Cat. No. 189825) in DMSO.

Altre note

Eggert, A., et al. 2001. Cancer Res.61, 1314.
Takebayashi, S., et al. 2001. Biochem. Biophys. Res. Commun.288, 921.
Zhu, W.G., et al. 2001. Cancer Res.61, 1327.
Hopkins-Donaldson, S., et al. 2000. Cancer Res.60, 4315.
Haaf, T. 1995. Pharmacol. Ther.65, 19.
Jones, P.A., and Taylor, S.M. 1980. Cell20, 85.

Note legali

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H341,H360

Classi di pericolo

Muta. 2 - Repr. 1B

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

188.6 °F - closed cup - (Dimethylsulfoxide)

Punto d’infiammabilità (°C)

87 °C - closed cup - (Dimethylsulfoxide)

Certificati d'analisi (COA)

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