14-595-M
PP1α Protein, 10 µg
Recombinant, full length, human PP1α, for use in Phosphatase Assays.
Sinonimo/i:
PPP1C, Phosphoprotein phosphatase 1, Phosphorylase phosphatase
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About This Item
Codice UNSPSC:
12352200
eCl@ss:
32160405
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in E. coli
Forma fisica
solution
Durata
6 mo.
PM
Mw 37.6 kDa
Produttore/marchio commerciale
Upstate®
tecniche
activity assay: suitable (phosphatase)
Solubilità
water: soluble
N° accesso NCBI
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... PPP1CA(5499)
Descrizione generale
Research area: Neuroscience
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Protein Phosphatase 1 (PP1) is one of the key serine/threonine-specific protein phosphatases.
Applicazioni
Research Category
Inflammation & Immunology
Inflammation & Immunology
Azioni biochim/fisiol
Protein Target: PP1α Target Sub-Family: Ser/Thr phosphatase
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Protein Phosphatase 1 (PP1) has been associated with a wide range of biological processes, including synaptic plasticity, cell cycle progression, dopaminergic neurotransmission, contraction, and glycogen metabolism, maintaining microtubule stability and the dephosphorylation of tau. Furthermore, PP-1 plays a vital role in synaptic development, plasticity, signaling, neurite outgrowth, synapse formation, ion channel function, and neurotransmission. Changes in PP-1 signaling within dendritic spines have been linked to various neurological and psychiatric disorders.
Confezionamento
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-595M when ordering the 250 µg size.
Qualità
routinely evaluated by dephosphorylation of 100μM DiFMUP
Stato fisico
Heparin agarose followed by Q agarose
Stoccaggio e stabilità
6 months at -20°C from date of shipment
Altre note
For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme
Note legali
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Avvertenze
Warning
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Skin Sens. 1
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 1
Certificati d'analisi (COA)
Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
The role of protein phosphatase-1 in the modulation of synaptic and structural plasticity.
Munton, Richard P, et al.
Febs Letters, 567, 121-128 (2004)
Modulation of dendritic spines by protein phosphatase-1
Advances in Pharmacology, 90.0, 117-144 (2021)
Alphonse Garcia et al.
Biochimie, 85(8), 721-726 (2003-10-31)
The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of
Targeting phosphatases as the next generation of disease modifying therapeutics for Parkinson?s disease
Braithwaite SP, et al.
Neurochemistry International, 61, 899-906 (2012)
Karl Foley et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 41(14), 3040-3050 (2021-04-09)
Protein phosphatases, by counteracting protein kinases, regulate the reversible phosphorylation of many substrates involved in synaptic plasticity, a cellular model for learning and memory. A prominent phosphatase regulating synaptic plasticity and neurologic disorders is the serine/threonine protein phosphatase 1 (PP1).
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