1.20091

Silice

EMPROVE^® ESSENTIAL, Ph. Eur., NF

• Sinonimo/i: Biossido di silicio
• Formula condensata: SiO₂
• Numero CAS: 7631-86-9
• Peso molecolare: 60.08
• Numero MDL: MFCD00011232
• Codice UNSPSC: 12352201

Proprietà

• agenzia: NF; Ph. Eur.
• Livello qualitativo: 500
• Nome Commerciale: EMPROVE^® ESSENTIAL
• Stato: fine powder
• Dimensione particelle: 17-25 μm (d50)
• P. ebollizione: 2230 °C (lit.)
• Punto di fusione: >1600 °C (lit.); 1710 °C
• applicazioni: pharmaceutical; pharmaceutical; solid formulation; solubility enhancement
• Temperatura di conservazione: 2-30°C
• Stringa SMILE: O=[Si]=O
• InChI: 1S/O2Si/c1-3-2; VYPSYNLAJGMNEJ-UHFFFAOYSA-N

Descrizione

Descrizione generale

With formulation challenges in mind, we have used particle engineering technologies to develop functional excipients specifically for solid dosage forms. The products in our Parteck^® portfolio feature unique particle properties tailored for excellent performance in tableting processes, for specific drug delivery technologies, or for solubility enhancement. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Applicazioni

Parteck^® SLC excipient is an innovative silica drug carrier that enhances drug solubility thanks to its unique surface structure, which can stabilize the amorphous state. This is especially relevant for poor glass forming APIs, which can be difficult to stabilize with other formulation technologies. Parteck^® SLC is also emerging as a first-in-class excipient to reduce the risk of unstable polymorphism and particle properties in drug development. In this application, Parteck^® SLC can homogenize both properties in a template-based formulation approach, with robust and reliable results.

Caratteristiche e vantaggi

• Solubility enhancement of APIs
• Unparalleled stabilization of the amorphous solid state
• Unique pore structure (6 nm diameter) and a very high surface area (500 m²/g)
• Perfect fit to stabilize poor glass former molecules
• Platform approach to manage API particle and polymorph variation
• No specific equipment/extra capital invest needed to stabilize the amorphous form of APIs
• High-end application support

Confezionamento

1200910300 // Wide necked plastic bottle in corrugated box
1200911000 // Wide necked plastic bottle in corrugated box
1200919025 // Standard PE bag in PE square drum

Note legali

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): nwg
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable