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870708P

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08:0 Coenzyme A

Avanti Research - A Croda Brand 870708P, powder

Sinonimo/i:

octanoyl Coenzyme A (ammonium salt)

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About This Item

Formula empirica (notazione di Hill):
C29H59N10O17P3S
Numero CAS:
Peso molecolare:
944.82
Codice UNSPSC:
12352211
NACRES:
NA.25

Forma fisica

powder

Confezionamento

pkg of 1 × 5 mg (870708P-5mg)

Produttore/marchio commerciale

Avanti Research - A Croda Brand 870708P

applicazioni

lipidomics

Tipo di lipide

coenzymes

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

O[C@@](C(NCCC(NCCSC(CCCCCCC)=O)=O)=O)(C(C)(COP([O-])(OP([O-])(OC[C@H]([C@H]1OP([O-])(O)=O)O[C@H]([C@@H]1O)N2C3=C(C(N)=NC=N3)N=C2)=O)=O)C)[H].[NH4+].[NH4+].[NH4+]

InChI

1S/C29H50N7O17P3S.3H3N/c1-4-5-6-7-8-9-20(38)57-13-12-31-19(37)10-11-32-27(41)24(40)29(2,3)15-50-56(47,48)53-55(45,46)49-14-18-23(52-54(42,43)44)22(39)28(51-18)36-17-35-21-25(30)33-16-34-26(21)36;;;/h16-18,22-24,28,39-40H,4-15H2,1-3H3,(H,31,37)(H,32,41)(H,45,46)(H,47,48)(H2,30,33,34)(H2,42,43,44);3*1H3/t18-,22?,23+,24+,28-;;;/m1.../s1
FTIQWXKUZWNHGD-DMTDIVBASA-N

Descrizione generale

08:0 Coenzyme A, also referred as octanoyl Coenzyme A, is a medium-chain acyl CoA. It is a coenzyme A derivative of octanoic acid.

Applicazioni

08:0 Coenzyme A has been used as a substrate in microsomal ghrelin octanoyltransferase assay.

Azioni biochim/fisiol

08:0 Coenzyme A acts as an intermediate in mitochondrial fatty acid β-oxidation. It hinders the activity of citrate synthase (CS) and glutamate dehydrogenase (GDH). Higher levels of octanoyl –CoA, due to reduced β-oxidation of octanoyl-CoA by medium-chain acyl CoA dehydrogenase (MCADH), is observed in patients with MCADH deficiency (MCD).

Confezionamento

5 mL Amber Glass Screw Cap Vial (870708P-5mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids


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B A Amendt et al.
The Journal of clinical investigation, 76(3), 963-969 (1985-09-01)
Medium-chain acyl-coenzyme A (CoA) dehydrogenase (MCADH; EC 1.3.99.3) deficiency (MCD) is an inborn error of beta-oxidation. We measured 3H2O formed by the dehydrogenation of [2,3-3H]acyl-CoAs in a 3H-release assay. Short-chain acyl-CoA dehydrogenase (SCADH; EC 1.3.99.2), MCADH, and isovaleryl-CoA dehydrogenase (IVDH;
Robert Modre-Osprian et al.
BMC systems biology, 3, 2-2 (2009-01-08)
The oxidation of fatty acids in mitochondria plays an important role in energy metabolism and genetic disorders of this pathway may cause metabolic diseases. Enzyme deficiencies can block the metabolism at defined reactions in the mitochondrion and lead to accumulation
J C Lai et al.
Research communications in chemical pathology and pharmacology, 82(3), 331-338 (1993-12-01)
We investigated the hypothesis that one mechanism underlying fatty acid toxicity is the selective inhibition of rate-limiting and/or regulated tricarboxylic acid cycle and related enzymes by fatty acyl coenzyme A (CoA) derivatives by examining the effects of several fatty acyl
Martin S Taylor et al.
Bioorganic chemistry, 62, 64-73 (2015-08-08)
Ghrelin-O-Acyltransferase (GOAT) is an 11-transmembrane integral membrane protein that octanoylates the metabolism-regulating peptide hormone ghrelin at Ser3 and may represent an attractive target for the treatment of type II diabetes and the metabolic syndrome. Protein octanoylation is unique to ghrelin

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