Passa al contenuto
Merck
Tutte le immagini(2)

Documenti fondamentali

857392O

Avanti

(R)-FTY720-OMe

(R)-2-amino-2-(methoxymethyl)-4-(4-octylphenyl)butan-1-ol, neat oil

Sinonimo/i:

(R)-FTY720-methyl ether; ROME

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali

Scegli un formato

1 MG
CHF 159.00

CHF 159.00


Spedizione prevista il22 maggio 2025


Richiedi un ordine bulk

Scegli un formato

Cambia visualizzazione
1 MG
CHF 159.00

About This Item

Formula empirica (notazione di Hill):
C20H35NO2
Numero CAS:
Peso molecolare:
321.50
Numero MDL:
Codice UNSPSC:
12352211
NACRES:
NA.25

CHF 159.00


Spedizione prevista il22 maggio 2025


Richiedi un ordine bulk

Saggio

>99% (TLC)

Stato

liquid

Confezionamento

pkg of 1 × 1 mg (857392O-1mg)

Produttore/marchio commerciale

Avanti Research - A Croda Brand 857392O

Tipo di lipide

sphingolipids
bioactive lipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Categorie correlate

Descrizione generale

(R)-FTY720-OMe is the analogue of FTY720.[1]
(R)-FTY720-OMe is a structural analogue of FTY720 which acts as a specific competitive inhibitor of sphingosine kinase 2 (SK2). Furthermore, (R)-FTY720-OMe does not inhibit sphingosine kinase 1 (SK1) activity.

Azioni biochim/fisiol

(R)-FTY720-OMe helps to block DNA synthesis and actin rearrangement induced by sphingosine 1-phosphate (S1P) in MCF-7 breast cancer cells. It can also reduce sphingosine kinase 2 (SK2) expression and prevent DNA synthesis in HEK 293 cells. (R)-FTY720-OMe has anti-breast cancer potential.[1]

Confezionamento

5 mL Amber Glass Screw Cap Vial (857392O-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3


Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documenti section.

Se ti serve aiuto, non esitare a contattarci Servizio Clienti

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

Francesca Tonelli et al.
British journal of pharmacology, 168(6), 1497-1505 (2012-11-02)
Sphingosine kinase catalyses the formation of sphingosine 1-phosphate and is linked with androgen receptor signalling in prostate cancer cells. Therefore, we investigated the effect of sphingosine kinase inhibitors on androgen receptor expression. Androgen-sensitive LNCaP cells were treated with SKi (2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole)
(R)-FTY720 methyl ether is a specific sphingosine kinase 2 inhibitor: effect on sphingosine kinase 2 expression in HEK 293 cells and actin rearrangement and survival of MCF-7 breast cancer cells
Lim KG, et al.
Cellular Signalling, 23(10), 1590-1595 (2011)
Keng Gat Lim et al.
Cellular signalling, 23(10), 1590-1595 (2011-05-31)
Sphingosine kinase 2 (SK2) catalyses the conversion of sphingosine to the bioactive lipid sphingosine 1-phosphate (S1P). We report here, the stereospecific synthesis of an analogue of FTY720 called (R)-FTY720-OMe, which we show is a competitive inhibitor of SK2. (R)-FTY720-OMe failed
David G Watson et al.
Cellular signalling, 25(4), 1011-1017 (2013-01-15)
Two isoforms of sphingosine kinase, SK1 and SK2, catalyze the formation of the bioactive lipid sphingosine 1-phosphate (S1P) in mammalian cells. We have previously shown that treatment of androgen-sensitive LNCaP prostate cancer cells with a non-selective SK isoform inhibitor, 2-(p-hydroxyanilino)-4-(p-chlorophenyl)thiazole

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.