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850338P

Avanti

MAPCHO™-14

n-tetradecylphosphocholine, powder

Sinonimo/i:

TPC; Fos-Choline-14; FOS14; FC-14

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1 G
CHF 305.00

CHF 305.00

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Cambia visualizzazione
1 G
CHF 305.00

About This Item

Formula empirica (notazione di Hill):
C19H42NO4P
Numero CAS:
77733-28-9
Peso molecolare:
379.51
Numero MDL:
MFCD00171705
Codice UNSPSC:
12352211
NACRES:
NA.25

CHF 305.00

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Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 1 g (850338P-1g)
pkg of 1 × 10 g (850338P-10g)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 850338P

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[P](=O)([O-])(OCC[N+](C)(C)C)OCCCCCCCCCCCCCC

InChI

1S/C19H42NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-18-23-25(21,22)24-19-17-20(2,3)4/h5-19H2,1-4H3
BETUMLXGYDBOLV-UHFFFAOYSA-N

Descrizione generale

MAPCHO™-14 is a fos-choline-based zwitterionic detergent.[1]
Tetradecylphosphocholine is a structural analog of myristoyl lysophosphatidylcholine that is more stable to hydrolytic degradation. The lipid is often used as a detergent for membrane protein solubilization and purification. It has been used as a helper lipid for in vitro and in vivo gene transfer, and it has been shown to have some anticancer activity.

Applicazioni

MAPCHO™-14 has been used as a supplement in extraction buffer (RIPA buffer).[2]

Azioni biochim/fisiol

Fos-choline-14 (N-tetradecylphosphocholine) is mainly used for solubilization and purification of proteins.[1]

Confezionamento

20 mL Clear Glass Screw Cap Vial (850338P-1g)
60 mL Amber Wide Mouth Screw Cap Glass Bottle (850338P-10g)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC
MAPCHO is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line
Cook BL, et al.
Testing, 3(8), e2920-e2920 (2008)
Brian L Cook et al.
PloS one, 3(8), e2920-e2920 (2008-08-07)
In order to begin to study the structural and functional mechanisms of olfactory receptors, methods for milligram-scale purification are required. Here we demonstrate the production and expression of a synthetically engineered human olfactory receptor hOR17-4 gene in a stable tetracycline-inducible
Pernille M Christensen et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 30(6), 2351-2359 (2016-03-10)
Apolipoprotein M (ApoM) transports sphingosine-1-phosphate (S1P) in plasma, and ApoM-deficient mice (Apom(-/-)) have ∼50% reduced plasma S1P levels. There are 5 known S1P receptors, and S1P induces adherens junction formation between endothelial cells through the S1P1 receptor, which in turn
Impaired endothelial barrier function in apolipoprotein M-deficient mice is dependent on sphingosine-1-phosphate receptor 1
Christensen PM, et al.
Faseb Journal, 30(6), 2351-2359 (2016)
Reinhard Zeisig et al.
Cancer gene therapy, 10(4), 302-311 (2003-04-08)
To improve liposomal gene transfer we investigated the influence of membrane-interacting alkylphospholipids (APLs) on gene transfer efficiency in vitro and in vivo using the LacZ reporter gene and the cytosine deaminase (CD) suicide gene. Liposomes were first optimized concerning the
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