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840861C

Avanti

18:0-18:1 PA

1-stearoyl-2-oleoyl-sn-glycero-3-phosphate (sodium salt), chloroform

Sinonimo/i:

1-octadecanoyl-2--(9Z-octadecenoyl)-sn-glycero-3-phosphate (sodium salt); SOPA; PA(18:0/18:1(9Z))

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25 MG
CHF 156.00

CHF 156.00

Spedizione prevista il24 aprile 2025

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25 MG
CHF 156.00

About This Item

Formula empirica (notazione di Hill):
C39H74O8PNa
Numero CAS:
384833-24-3
Peso molecolare:
724.96
Numero MDL:
MFCD02259260
Codice UNSPSC:
51191904
NACRES:
NA.25

CHF 156.00

Spedizione prevista il24 aprile 2025

Richiedi un ordine bulk

Saggio

>99% (TLC)

Stato

liquid

Confezionamento

pkg of 1 × 2.5 mL (840861C-25mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 840861C

Concentrazione

10 mg/mL (840861C-25mg)

Tipo di lipide

phospholipids

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Stringa SMILE

[Na+].[P](=O)([O-])(OC[C@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC)O

InChI

1S/C39H75O8P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-38(40)45-35-37(36-46-48(42,43)44)47-39(41)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h18,20,37H,3-17,19,21-36H2,1-2H3,(H2,42,43,44);/q;+1/p-1/b20-18-;/t37-;/m1./s1
QTWIAVIWKTYOHY-HTNAYUJGSA-M

Categorie correlate

Descrizione generale

18:0-18:1 PA (1-stearoyl-2-oleoyl-sn-glycero-3-phosphate) is an unsaturated phosphatidic acid (PA) derivative.[1] PA is present in the biomembranes.[2] It is the simplest glycerophospholipid.[3]

Applicazioni

18:0-18:1 PA (1-stearoyl-2-oleoyl-sn-glycero-3-phosphate (sodium salt)) may be used:
  • as a phosphatidic acid (PA) standard to identify the corresponding radiolabeled PA on the thin-layer chromatography (TLC)[4]
  • in vesicles for experimental validation in order to identify novel phospholipids capable of inhibiting cellular membrane transportation by (ATP)-binding cassette P-glycoprotein (P-gp)[1]
  • to treat young adult mouse colonic (YAMC) cells prior to nanoclustering- forster resonance energy transfer (FRET) analysis(6)

Azioni biochim/fisiol

Phosphatidic acid (PA) is the precursor for other phospholipids and acts as a signaling molecule.[2]

Confezionamento

5 mL Clear Glass Sealed Ampule (840861C-25mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Pittogrammi

Skull and crossbonesHealth hazard
GHS06,GHS08

Avvertenze

Danger

Classi di pericolo

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

Organi bersaglio

Central nervous system, Liver,Kidney

Classe di pericolosità dell'acqua (WGK)

WGK 3

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Certificati d'analisi (COA)

Lot/Batch Number

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Jolanta Zegarlińska et al.
Acta biochimica Polonica, 65(2), 163-171 (2018-06-19)
Phosphatidic acid (PA) is the simplest glycerophospholipid naturally occurring in living organisms, and even though its content among other cellular lipids is minor, it is drawing more and more attention due to its multiple biological functions. PA is a precursor
Xavier Lucas et al.
PloS one, 8(4), e60679-e60679 (2013-04-18)
P-glycoprotein is capable of effluxing a broad range of cytosolic and membrane penetrating xenobiotic substrates, thus leading to multi-drug resistance and posing a threat for the therapeutic treatment of several diseases, including cancer and central nervous disorders. Herein, a virtual
Natividad R Fuentes et al.
Cancer research, 78(14), 3899-3912 (2018-05-18)
Ras signaling originates from transient nanoscale compartmentalized regions of the plasma membrane composed of specific proteins and lipids. The highly specific lipid composition of these nanodomains, termed nanoclusters, facilitates effector recruitment and therefore influences signal transduction. This suggests that Ras
Y Liu et al.
American journal of physiology. Lung cellular and molecular physiology, 295(3), L471-L478 (2008-07-16)
We have previously reported the participation of mitogen-activated protein, Rho, and phosphoinositide-3 (PI3) kinases in separate pathways in serotonin (5-HT)-induced proliferation of pulmonary artery smooth muscle cells (SMCs). In this study, we investigated the possible participation of phospholipase D (PLD)
Tingting Wang et al.
Frontiers in endocrinology, 9, 221-221 (2018-05-22)
Searching for nutraceuticals and understanding the underlying mechanism that promote fish growth is at high demand for aquaculture industry. In this study, the modulatory effects of soy phosphatidic acids (PA) on cell proliferation, nutrient sensing, and metabolic pathways were systematically

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