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810174P

Avanti

16:0-12:0 NBD PA

Avanti Research™ - A Croda Brand 810174P, powder

Sinonimo/i:

1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt)

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1 MG
CHF 262.00

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1 MG
CHF 262.00

About This Item

Formula empirica (notazione di Hill):
C37H66N5O11P
Numero CAS:
474942-96-6
Peso molecolare:
787.92
Numero MDL:
MFCD00467278
Codice UNSPSC:
12352211
NACRES:
NA.25

CHF 262.00

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Saggio

>99% (TLC)

Stato

powder

Confezionamento

pkg of 1 × 1 mg (810174P-1mg)

Produttore/marchio commerciale

Avanti Research™ - A Croda Brand 810174P

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Descrizione generale

Phosphatidic acid (PA) is a simple anionic cellular glycerophospholipid possessing a phosphomonoester polar head group and two long hydrophobic acyl chains.[1] 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PA is a fluorophore labeled phospholipid having 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.[2]

Applicazioni

16:0-12:0 NBD PA or 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable:
  • to incubate cells for the imaging of lyso phosphatidylcholine (PC) in P. falciparum live cells[3]
  • as a component of separation buffer for the separation of phosphoinositides and sphingolipids in the microchip devices[4]
  • in cytidine diphosphate diacylglycerol (CDP-DAG) synthase activity assay[5]

Azioni biochim/fisiol

Phosphatidic acid (PA) influences membrane fusion and membrane fission events[1] and membrane curvature.[6] It acts as a signaling molecule for various cellular processes including membrane trafficking and sperm hyper-activation.[7]

Confezionamento

5 mL Amber Glass Screw Cap Vial (810174P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Codice della classe di stoccaggio

11 - Combustible Solids

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Certificati d'analisi (COA)

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Tam41 is a CDP-diacylglycerol synthase required for cardiolipin biosynthesis in mitochondria
Tamura Y, et al.
Cell Metabolism, 17(5), 709-718 (2013)
Yasushi Tamura et al.
Cell metabolism, 17(5), 709-718 (2013-04-30)
CDP-diacylglycerol (CDP-DAG) is central to the phospholipid biosynthesis pathways in cells. A prevailing view is that only one CDP-DAG synthase named Cds1 is present in both the endoplasmic reticulum (ER) and mitochondrial inner membrane (IM) and mediates generation of CDP-DAG
Priya Putta et al.
Biochimica et biophysica acta, 1858(11), 2709-2716 (2016-08-03)
Phosphatidic acid (PA) is a crucial membrane phospholipid involved in de novo lipid synthesis and numerous intracellular signaling cascades. The signaling function of PA is mediated by peripheral membrane proteins that specifically recognize PA. While numerous PA-binding proteins are known
Phosphatidic acid binding proteins display differential binding as a function of membrane curvature stress and chemical properties
Putta P, et al.
Biochimica et Biophysica Acta, 1858(11), 2709-2716 (2016)
Mikhail A Zhukovsky et al.
FEBS letters, 593(17), 2428-2451 (2019-08-01)
Phosphatidic acid (PA) is the simplest cellular glycerophospholipid characterized by unique biophysical properties: a small headgroup; negative charge; and a phosphomonoester group. Upon interaction with lysine or arginine, PA charge increases from -1 to -2 and this change stabilizes protein-lipid
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