700078P

7α,25-dihydroxycholesterol-d6

Avanti Research^™ - A Croda Brand

• Sinonimo/i: 26,26,26,27,27,27-hexadeutero-7α,25-dihydroxycholesterol ; 111117
• Formula empirica (notazione di Hill): C₂₇H₄₀D₆O₃
• Numero CAS: 2260669-11-0
• Peso molecolare: 424.69
• Codice UNSPSC: 41141804
• NACRES: NA.25

Proprietà

• Descrizione: 7α,25-dihydroxycholesterol-d6
• Saggio: >99% (TLC)
• Stato: powder
• Confezionamento: pkg of 1 × 1 mg (700078P-1mg)
• Produttore/marchio commerciale: Avanti Research^™ - A Croda Brand
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• Stringa SMILE: [H][C@@]12[C@]([C@](CC[C@H](O)C3)(C)C3=C[C@H]2O)([H])CC[C@@]4(C)[C@@]1([H])CC[C@]4([H])[C@]([H])(C)CCCC(O)(C([2H])([2H])[2H])C([2H])([2H])[2H]
• InChI: 1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1/i2D3,3D3; BQMSKLCEWBSPPY-WWCTWMKLSA-N

Descrizione

Descrizione generale

7α,25-dihydroxycholesterol (7α,25-OHC) is synthesized by the hydroxylation of cholesterol by the action of enzyme cholesterol 25-hydroxylase (CH25H) and cytochrome P450, family 7, subfamily b, polypeptide 1 (CYP7B1).[1] The catabolic breakdown of 7α,25-OHC to bile acid precursors is catalyzed by the enzymes hydroxy-Δ-5-steroid dehydrogenase, 3β- and steroid Δ-isomerase 7 (HSD3B7).[2] 7α,25-dihydroxycholesterol-d6 is the deuterated form of 7α,25-dihydroxycholesterol.

Applicazioni

7α,25-dihydroxycholesterol-d6 has be used as an internal standard in liquid chromatography electrospray ionization tandem mass spectrometric (LC–ESI-MS/MS) analysis of human plasma.[3]

Azioni biochim/fisiol

7α,25-dihydroxycholesterol (7α,25-OHC) serves as an endogenous ligand for G-protein-coupled receptor 183 (GPR183) or Epstein-Barr virus-induced gene 2 (EBI2). It plays a key role in the migration of type 3 innate lymphoid cells (ILC3) in the small intestine and colon. 7α,25-OHC mediates immune cell migration functionality by their chemoattractant property.[1] Inhibition of 7α,25-OHC synthesis leads to impairment in the migration of B cells.[4]

Confezionamento

5 mL Amber Glass Screw Cap Vial (700078P-1mg)

Note legali

Avanti Research is a trademark of Avanti Polar Lipids, LLC

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Punto d’infiammabilità (°F): No data available
• Punto d’infiammabilità (°C): No data available