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SML0541

7α,25-Dihydroxycholesterol

≥98% (HPLC), powder, GPR183 agonist

Sinonimo/i:

5-Cholesten-3β,7α,25-triol

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Cambia visualizzazione
Voi/SKUDisponibilitàPrezzo
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 376.00
25 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 1530.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C27H46O3
Numero CAS:
64907-22-8
Peso molecolare:
418.65
UNSPSC Code:
12352211
PubChem Substance ID:
329825542
NACRES:
NA.77
MDL number:
MFCD20488904
Assay:
≥98% (HPLC)
Form:
powder

CHF 376.00

Per conoscere la disponibilità, visualizza il carrello
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Nome del prodotto

7α,25-Dihydroxycholesterol, ≥98% (HPLC)

Quality Segment

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL (clear solution)

storage temp.

2-8°C

SMILES string

C[C@H](CCCC(C)(C)O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C

InChI

1S/C27H46O3/c1-17(7-6-12-25(2,3)30)20-8-9-21-24-22(11-14-27(20,21)5)26(4)13-10-19(28)15-18(26)16-23(24)29/h16-17,19-24,28-30H,6-15H2,1-5H3/t17-,19+,20-,21+,22+,23-,24+,26+,27-/m1/s1

InChI key

BQMSKLCEWBSPPY-IKVTXIKFSA-N

Application

7α,25-Dihydroxycholesterol has been used as a ligand for G protein-coupled receptor 183 (Gpr183).

Biochem/physiol Actions

7α,25-Dihydroxycholesterol (7α,25-OHC) is a potent and selective endogenous ligand for the orphan GPCR receptor EBI2 (GPR183) with an EC50 value in the picomolar range. The newly discovered EBI2–oxysterol signalling pathway has been shown to have an important role in the adaptive immune response, including a role in driving immune cell migration. In vitro and in vivo studies showed that 7,25-OHC can serve as a chemokine directing migration of B cells, T cells and dendritic cells.
7α,25-Dihydroxycholesterol is a potent agonist of the orphan GPCR receptor EBI2 (GPR183); directs immune cell migration.
7α,25-Dihydroxycholesterol has an ability to block the early steps of T-cell activation.

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Questo articolo
700080P700024P700096P
7α,25-Dihydroxycholesterol ≥98% (HPLC)

Sigma-Aldrich

SML0541

7α,25-Dihydroxycholesterol

7α,25-dihydroxycholesterol Avanti Research™ - A Croda Brand

Avanti

700080P

7α,25-dihydroxycholesterol

7α,27-dihydroxycholesterol Avanti Research™ - A Croda Brand

Avanti

700024P

7α,27-dihydroxycholesterol

7α,24(S)-dihydroxycholesterol Avanti Research™ - A Croda Brand

Avanti

700096P

7α,24(S)-dihydroxycholesterol

description

≥98% (HPLC)

description

Avanti Research™ - A Croda Brand

description

Avanti Research™ - A Croda Brand

description

Avanti Research™ - A Croda Brand

assay

≥98% (HPLC)

assay

>99% (TLC)

assay

>99% (TLC)

assay

>99% (TLC)

form

powder

form

powder

form

powder

form

powder

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

solubility

DMSO: 5 mg/mL (clear solution)

solubility

-

solubility

-

solubility

-

color

white to beige

color

-

color

-

color

-

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Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 3

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

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Questions

  1. What the optimal dissolvent of the compound for in vivo mouse injection?

    1 answer

    1. This product is soluble in DMSO at a concentration of 5 mg/mL. This stock solution can then be diluted with aqueous solutions such as PBS. This product is not sterile and has not been tested for in vivo or in vitro use.

      Please see the link below to review articles that may offer additional information for mouse studies:
      https://www.sigmaaldrich.com/US/en/search/sml0541?focus=papers&page=1&perpage=30&sort=relevance&term=sml0541&type=citation_search.

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