Journal of chromatography, 622(2), 179-186 (1993-12-22)
O-Hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) is a chiral organophosphorus compound that undergoes enzymatic hydrolysis in the rat and hen. Studies of the stereospecificity of its biodegradation are necessary to establish HDCP toxicity. To this effect, methods have been developed for the
Archives of environmental health, 50(4), 277-280 (1995-07-01)
p-Dichlorobenzene is used widely in the United States as a room deodorizer, a moth repellent, and a precursor for a polymer. In a previous study of selected children in Arkansas, we found that 96% of the children had detectable urinary
In humans, the metabolism of environmental phenols may include the formation of conjugated species (e.g., glucuronides and sulfates), but the free species-not the conjugated forms-are considered biologically active. Therefore, information on the concentration of these free species in blood or
Archives of environmental contamination and toxicology, 43(4), 481-485 (2002-10-26)
The relationship between exposure to p-dichlorobenzene (p-DCB) and urinary excretion of 2,5-dichlorophenol (2,5-DCP), the major metabolite of p-DCB, was examined to evaluate the usefulness of the metabolite as a biological index for low-level exposure of p-DCB in the general population.
The organophosphorus (OP) compound O-hexyl-O-2,5-dichlorophenyl phosphoramidate (H-DCP) is hydrolysed in the plasma, liver and brain of hens and rats. We study in hen plasma the effect of tissue and substrate concentrations and of pH on the hydrolysing activity of H-DCP.
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