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911550

Sigma-Aldrich

Bis-MPA-RAFT dendrimer

trimethylol propane core, generation 1

Sinonimo/i:

CTA functionalized dendrimer, Multi-arm RAFT

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About This Item

Formula empirica (notazione di Hill):
C99H104N6O18S12
Peso molecolare:
2050.69
Codice UNSPSC:
12162002
NACRES:
NA.23

Forma fisica

solid

PM

generation 1

N° gruppi superficiali

6

Colore

orange to red

Temperatura di conservazione

−20°C

Categorie correlate

Descrizione generale

  • Polymer architecture: Dendrimer
  • Generation: 1
  • End Group Functionality: RAFT
  • No. Surface Groups: 6
  • Calculated Mol. Wt.: 2050.7 g/mol
  • bis-MPA = 2,2-Bis(hydroxymethyl)propionic acid

Applicazioni

Bis-MPA dendritic molecules are based on 2,2-bismethylolpropionicacid (bis-MPA) building blocks. The hydrolysable linkers presented in this type of polymers allow their degradation into byproducts that can be reabsorbed by the body or into excretable non-toxic small molecules. Therefore, this group of dendritic polymers is biocompatible and biodegradable, making them suitable for biomedical applications.
The corona of this product is functionalized with RAFT agents, which allow direct controlled polymerization from the dendrimer surface. It can be readily used to construct multi-arm polymer structure using suitable acrylic monomers.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Chemistry of multifunctional polymers based on bis-MPA and their cutting-edge applications
Garcia-Gallego, S. et al.
Progress in Polymer Science, 48, 85-110 (2015)
Patrik Stenström et al.
Molecules (Basel, Switzerland), 23(8) (2018-08-17)
Herein, we present the first evaluation of cationic dendrimers based on 2,2-bis(methylol)propionic acid (bis-MPA) as nonviral vectors for transfection of short interfering RNA (siRNA) in cell cultures. The study encompassed dendrimers of generation one to four (G1⁻G4), modified to bear
Anna Carlmark et al.
Chemical Society reviews, 42(13), 5858-5879 (2013-05-01)
Dendritic polymers are highly branched, globular architectures with multiple representations of functional groups. These nanoscale organic frameworks continue to fascinate researchers worldwide and are today under intensive investigation in application-driven research. A large number of potential application areas have been

Articoli

Dendritic Polyester Scaffolds for Drug Delivery

Dendritic molecules' biomedical applications, particularly bis-MPA dendritic scaffolds, hold promise for drug delivery.

New Multi-Dendrimer Platforms for Supramolecular Assembly

Dendrimers, polymer nanostructures, are synthesized for specific purposes by manipulating critical nanoscale design parameters (CNDPs).

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