902675

BocNH-PEG₆-acid

• Sinonimo/i: 2,2-Dimethyl-4-oxo-3,8,11,14,17,20,23-heptaoxa-5-azapentacosan-25-oic acid, Boc-NH-PEG6-CH₂COOH
• Formula empirica (notazione di Hill): C₁₉H₃₇NO₁₀
• Numero CAS: 391684-36-9
• Peso molecolare: 439.50
• Numero MDL: MFCD30489670
• Codice UNSPSC: 12352106
• NACRES: NA.22

Proprietà

• Stato: liquid
• Impiego in reazioni chimiche: reagent type: linker
• Indice di rifrazione: n/D 1.4657
• Gruppo funzionale: Boc; amine; carboxylic acid
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC(COCCOCCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O
• InChI: 1S/C19H37NO10/c1-19(2,3)30-18(23)20-4-5-24-6-7-25-8-9-26-10-11-27-12-13-28-14-15-29-16-17(21)22/h4-16H2,1-3H3,(H,20,23)(H,21,22); ZKCDWMFMVAYYED-UHFFFAOYSA-N

Descrizione

Applicazioni

This heterobifunctional, PEGylated crosslinker features a carboxylic acid at one end and Boc-protected amino group at the other, which can be deprotected with mildly acidic conditions. The hydrophillic PEG linker facilitates solubility in biological applications. BocNH-PEG₆-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC^® molecules) for targeted protein degradation.

Altre note

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Ultrasmall particle of iron oxide-RGD peptidomimetic conjugate: synthesis and characterization

Note legali

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable