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779776

Sigma-Aldrich

Methyl-β-cyclodextrin

Wacker Chemie AG, ≥95.0% cyclodextrin basis (calculated)

Sinonimo/i:

Cavasol® W7 M, Methyl-beta-cyclodextrin

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100 G
CHF 485.00
500 G
CHF 998.00
10 KG
CHF 2’200.00

CHF 485.00

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Cambia visualizzazione
100 G
CHF 485.00
500 G
CHF 998.00
10 KG
CHF 2’200.00

About This Item

Numero CAS:
128446-36-6
Numero MDL:
MFCD00066764
Codice UNSPSC:
12352201
NACRES:
NA.22

CHF 485.00

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Saggio

≥95.0% cyclodextrin basis (calculated)

Stato

powder

Produttore/marchio commerciale

Wacker Chemie AG

Grado di funzionalizzazione

1.6-1.9 molar substitution

Impurezze

≤0.2% unsubstituted cyclodextrin
≤0.2% volatile organics
≤2% chloride

Perdita

≤7.0% loss on drying

Punto di fusione

180-182 °C (lit.)

Stringa SMILE

O1C2OC(C(OC3OC(C(OC4OC(C(OC5OC(C(OC6OC(C(OC7OC(C(OC8OC(C1C(C8OC)O)COC)C(C7OC)O)COC)C(C6OC)O)COC)C(C5OC)O)COC)C(C4OC)O)COC)C(C3OC)O)COC)C(C2OC)O)COC

InChI

1S/C56H98O35/c1-64-15-22-36-29(57)43(71-8)50(78-22)86-37-23(16-65-2)80-52(45(73-10)30(37)58)88-39-25(18-67-4)82-54(47(75-12)32(39)60)90-41-27(20-69-6)84-56(49(77-14)34(41)62)91-42-28(21-70-7)83-55(48(76-13)35(42)63)89-40-26(19-68-5)81-53(46(74-11)33(40)61)87-38-24(17-66-3)79-51(85-36)44(72-9)31(38)59/h22-63H,15-21H2,1-14H3
QGKBSGBYSPTPKJ-UHFFFAOYSA-N

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Applicazioni

Methyl-β-cyclodextrin (M-β-CD) can be used as a reactant to prepare ternary inclusion complex of diclofenac (DCF) in the presence of monoethanolamine (MEA). This complex improves the percutaneous absorption of DCF in human skin.[1] It can also be used to form an inclusion complex with olanzapine (OLP) to increase its solubility for efficient drug delivery.[2]

Altre note

For R&D Use

Note legali

Cavasol is a registered trademark of Wacker Chemie AG

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

368.6 °F

Punto d’infiammabilità (°C)

187 °C

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Certificati d'analisi (COA)

Lot/Batch Number
BCCN1027
BCCM7217
BCCJ1949
BCCJ7507
BCCJ0085

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Inclusion complex of methyl-β -cyclodextrin and olanzapine as potential drug delivery system for schizophrenia
de Freitas MR, et al.
Carbohydrate Polymers, 89(4), 1095-1100 (2012)
María Julia Mora et al.
European journal of medicinal chemistry, 45(9), 4079-4088 (2010-06-23)
Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-beta-cyclodextrin (M-beta-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state.
Sara Rodríguez-Acebes et al.
The Biochemical journal, 420(2), 305-315 (2009-03-06)
Cholesterol homoeostasis is critical for cell viability and proliferation. The SREBP (sterol regulatory element-binding protein) pathway is crucial for the maintenance of cholesterol homoeostasis. This pathway is controlled by cholesterol and cholesterol-derived oxysterols. J774 cells cannot convert desmosterol into cholesterol
Mario Menschikowski et al.
Cancer cell international, 11, 4-4 (2011-02-16)
Increasing evidences show that beyond its role in coagulation, endothelial protein C receptor (EPCR) interferes with carcinogenesis. Pro-carcinogenic effects of EPCR were linked with a raised generation of activated protein C (aPC) and anti-apoptotic signalling. This study was carried out
Laurie Hamtiaux et al.
PloS one, 6(10), e26823-e26823 (2011-11-03)
The antitumoral properties of endocannabinoids received a particular attention these last few years. Indeed, these endogenous molecules have been reported to exert cytostatic, apoptotic and antiangiogenic effects in different tumor cell lines and tumor xenografts. Therefore, we investigated the cytotoxicity
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