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764736

Sigma-Aldrich

Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane

PEG average Mn 2,000, PDLLA average Mn 2,000

Sinonimo/i:

PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA

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About This Item

Codice UNSPSC:
12162002
NACRES:
NA.23

Forma fisica

pellets

PM

PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)

Tempo di degradazione

2-5 weeks

Temp. transizione

Tm 29-33 °C

Ind. polidispersione

<1.1 (typical PEG)
<1.2
<1.3 (overall)

Temperatura di conservazione

2-8°C

Categorie correlate

Descrizione generale

Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†

Applicazioni

Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.

Caratteristiche e vantaggi

  • Good biocompatibility, low immunogenicity and good degradability.
  • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

>230.0 °F

Punto d’infiammabilità (°C)

> 110 °C

Certificati d'analisi (COA)

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Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide) PEG average Mn 2,000, PLGA average Mn 11,500

Sigma-Aldrich

764760

Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)

Arunvel Kailasan et al.
Acta biomaterialia, 6(3), 1131-1139 (2009-09-01)
This work describes the synthesis and characterization of novel thermoresponsive highly branched polyamidoamine-polyethylene glycol-poly(D,L-lactide) (PAMAM-PEG-PDLLA) core-shell nanoparticles. A series of dendritic PEG-PDLLA nanoparticles were synthesized through conjugation of PEG of various chain lengths (1500, 6000 and 12,000 g mol(-1)) to
Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing

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