638099

CyJohnPhos

97%

• Sinonimo/i: 2-(Dicyclohexylphosphino)biphenyl, (2-Biphenyl)dicyclohexylphosphine, Cyclohexyl JohnPhos
• Formula empirica (notazione di Hill): C₂₄H₃₁P
• Numero CAS: 247940-06-3
• Peso molecolare: 350.48
• Beilstein: 8440533
• Numero MDL: MFCD01862441
• Codice UNSPSC: 12352002
• ID PubChem: 24882909
• NACRES: NA.22

Proprietà

• Livello qualitativo: 100
• Saggio: 97%
• Impiego in reazioni chimiche: reaction type: Cross Couplings; reagent type: ligand; reaction type: Arylations; reagent type: ligand; reaction type: Buchwald-Hartwig Cross Coupling Reaction; reagent type: ligand; reaction type: C-X Bond Formation; reagent type: ligand; reaction type: Hiyama Coupling; reagent type: ligand; reaction type: Methylations; reagent type: ligand; reaction type: Negishi Coupling; reagent type: ligand; reaction type: Oxidations; reagent type: ligand; reaction type: Suzuki-Miyaura Coupling
• Punto di fusione: 102-106 °C (lit.)
• Gruppo funzionale: phosphine
• Stringa SMILE: C1CCC(CC1)P(C2CCCCC2)c3ccccc3-c4ccccc4
• InChI: 1S/C24H31P/c1-4-12-20(13-5-1)23-18-10-11-19-24(23)25(21-14-6-2-7-15-21)22-16-8-3-9-17-22/h1,4-5,10-13,18-19,21-22H,2-3,6-9,14-17H2; LCSNDSFWVKMJCT-UHFFFAOYSA-N

Descrizione

Descrizione generale

CyJohnPhos [(2-Biphenyl)dicyclohexylphosphine] is an air-stable, bulky and electron-rich monodentate biarylphosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions.

Learn more about Buchwald Phosphine Ligands

Applicazioni

CyJohnPhos may be used in combination with a nickel catalyst for the Suzuki-Miyaura arylation of tertiary benzylic acetates with aryl boroxines to produce diaryl and triaryl quaternary stereocenters.

Ligand employed in the palladium-catalysed synthesis of 1,3,5-tris(2′-aminophenyl)benzene, a core building block for potential ionic receptors.

Ligand for amination of aryl halides and triflates.

Note legali

Usage subject to US Patents 6307087 and 6395916.

Informazioni sulla sicurezza

• Indicazioni di pericolo: H413
• Classi di pericolo: Aquatic Chronic 4
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)