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284270

Sigma-Aldrich

Phosphonoacetic acid

98%

Sinonimo/i:

(Carboxymethyl)phosphonic acid, 2-Phosphonoacetic acid, Fosfonoacetic acid, Phosphonacetic acid

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10 G
CHF 100.00
50 G
CHF 408.00

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10 G
CHF 100.00
50 G
CHF 408.00

About This Item

Formula condensata:
(HO)2P(O)CH2CO2H
Numero CAS:
4408-78-0
Peso molecolare:
140.03
Numero CE:
224-558-1
Numero MDL:
MFCD00004311
Codice UNSPSC:
12352100
ID PubChem:
24857145
NACRES:
NA.22

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Saggio

98%

Stato

powder or crystals

Punto di fusione

143-146 °C (lit.)

Solubilità

water: soluble 100 mg/mL, clear to very slightly hazy, colorless

Gruppo funzionale

carboxylic acid

Stringa SMILE

OC(=O)CP(O)(O)=O

InChI

1S/C2H5O5P/c3-2(4)1-8(5,6)7/h1H2,(H,3,4)(H2,5,6,7)
XUYJLQHKOGNDPB-UHFFFAOYSA-N

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Descrizione generale

Phosphonoacetic acid inhibits specifically human cytomegalovirus DNA synthesis in virus-infected human fibroblasts[1]. It also inhibits the synthesis of herpes simplex virus DNA in infected cells and the activity of the virus-specific DNA polymerase in vitro[2].

Applicazioni

Phosphonoacetic acid was used as an inhibitor of viral DNA replication, to investigate the infected cell protein 0 (bICP0) localization in infected low passage bovine cells[3]. It was also used as a phosphorus source for microbial growth in phosphate-independent manner[4].

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

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Certificati d'analisi (COA)

Lot/Batch Number
MKCW3645
MKCT6904
MKCT0828
MKBC4049
03598PJ

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Lauren M Oko et al.
PLoS pathogens, 15(6), e1007849-e1007849 (2019-06-06)
Virus-host interactions are frequently studied in bulk cell populations, obscuring cell-to-cell variation. Here we investigate endogenous herpesvirus gene expression at the single-cell level, combining a sensitive and robust fluorescent in situ hybridization platform with multiparameter flow cytometry, to study the
Vincent Li et al.
Journal of molecular biology, 400(3), 295-308 (2010-05-25)
Structure-based protein sequence alignments of family B DNA polymerases revealed a conserved motif that is formed from interacting residues between loops from the N-terminal and palm domains and between the N-terminal loop and a conserved proline residue. The importance of
T Sairenji et al.
The Journal of general virology, 38(1), 111-120 (1978-01-01)
This study investigated the synthesis of membrane antigen (MA) as well as virus capsid antigen (VCA) and early antigen (EA) in Daudi cells which had been superinfected with the P3HR-1 strain of Epstein-Barr virus (EBV) and then treated with trypsin
A Abendroth et al.
Journal of virology, 75(10), 4878-4888 (2001-04-20)
We sought to examine the effects of varicella-zoster virus (VZV) infection on the expression of major histocompatibility complex class I (MHC I) molecules by human fibroblasts and T lymphocytes. By flow cytometry, VZV infection reduced the cell surface expression of
Magdalena Klimek-Ochab
Folia microbiologica, 59(5), 375-380 (2014-02-27)
A psychrophilic fungal strain of Geomyces pannorum P15 was screened for its ability to utilize a range of synthetic and natural organophosphonate compounds as the sole source of phosphorus, nitrogen, or carbon. Only phosphonoacetic acid served as a phosphorus source
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