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Merck
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Documenti

240931

Sigma-Aldrich

Saccharin

≥99%

Sinonimo/i:

2,3-Dihydroxy-1,2-benzisothiazol-3-one-1,1-dioxide, 2-Sulfobenzoic acid imide, o-Benzoic sulfimide

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About This Item

Formula empirica (notazione di Hill):
C7H5NO3S
Numero CAS:
81-07-2
Peso molecolare:
183.18
Beilstein:
6888
Numero CE:
201-321-0
Numero MDL:
MFCD00005866
Codice UNSPSC:
12352100
ID PubChem:
24854444
NACRES:
NA.22

Saggio

≥99%

Forma fisica

powder

Punto di fusione

226-229 °C (lit.)

Solubilità

acetone: 1g in 12mL(lit.)
alcohol: 1g in 31mL(lit.)
boiling water: 1g in 25mL(lit.)
water: 1g in 25mL(lit.)

Stringa SMILE

O=C1NS(=O)(=O)c2ccccc12

InChI

1S/C7H5NO3S/c9-7-5-3-1-2-4-6(5)12(10,11)8-7/h1-4H,(H,8,9)
CVHZOJJKTDOEJC-UHFFFAOYSA-N

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Descrizione generale

The biodegradation of saccharin (2-sulfobenzoic acid imide), an artificial sweetening agent, was studied. It was also studied for its carcinogenic potential.

Applicazioni


  • Gabapentin-saccharin co-crystals with enhanced physicochemical properties and in vivo absorption formulated as oro-dispersible tablets.: This study presents the formulation of gabapentin-saccharin co-crystals, demonstrating improved solubility and absorption, beneficial for pharmaceutical applications (Soliman et al., 2020, doi: 10.1080/10837450.2019.1687521).

  • Improving the solubility, dissolution, and bioavailability of Ibrutinib by preparing it in a coamorphous state with saccharin.: The research focuses on enhancing the bioavailability of Ibrutinib through coamorphous preparation with saccharin, which is significant for cancer treatment (Shi et al., 2019, doi: 10.1016/j.xphs.2019.04.031).

Azioni biochim/fisiol

A sweet tastant for mammals. A glycerol taste receptor binding site specific for glucose has been proposed in drosophila.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Saccharin calcium United States Pharmacopeia (USP) Reference Standard

USP

1607029

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Methyl 2-(aminosulfonyl)benzoate 98%

Sigma-Aldrich

245232

Methyl 2-(aminosulfonyl)benzoate

Sodium Cyclamate analytical standard

Supelco

47827

Sodium Cyclamate

Sucralosio ≥98.0% (HPLC)

Sigma-Aldrich

69293

Sucralosio

Saccharin Sodium Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1348

Saccharin Sodium

Mettler-Toledo Calibration substance ME 51143091, Saccharin traceable to primary standards (LGC)

Supelco

41131

Mettler-Toledo Calibration substance ME 51143091, Saccharin

Sucralosio analytical standard

Supelco

90984

Sucralosio

N H Tran et al.
Bioresource technology, 161, 40-46 (2014-04-01)
The biodegradation of the six artificial sweetening agents including acesulfame (ACE), aspartame (ASP), cyclamate (CYC), neohesperidindihydrochalcone (NHDC), saccharin (SAC), and sucralose (SUC) by nitrifying activated sludge was first examined. Experimental results showed that ASP and NHDC were the most easily
Hellmuth Lilienthal et al.
Toxicology, 311(1-2), 52-60 (2013-02-14)
Many chemicals are known to exhibit endocrine activity and affect reproductive functions in vertebrates and invertebrates. Endocrine effects include influences on sexual differentiation of the brain during development and reproductive and non-reproductive behavior in adult offspring. We previously demonstrated that
Katharine J Tuerke et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(40), 13709-13717 (2012-10-05)
A taste associated with emetic drugs produces conditioned disgust reactions in rats (predominantly gaping), unlike nonemetic drugs that can still produce conditioned taste avoidance but not conditioned disgust. That difference suggests nausea is a prerequisite for learning disgust reactions to
Rino Ragno et al.
Journal of medicinal chemistry, 50(6), 1241-1253 (2007-02-28)
The screening of the inhibition capabilities of dye-like small molecules from a focused library against both human PRMT1 and Aspergillus nidulans RmtA is reported as well as molecular modeling studies (homology modeling, molecular docking, and 3-D QSAR) of the catalytic
Hugh P Morgan et al.
The Biochemical journal, 448(1), 67-72 (2012-08-22)
PYK (pyruvate kinase) plays a central role in the metabolism of many organisms and cell types, but the elucidation of the details of its function in a systems biology context has been hampered by the lack of specific high-affinity small-molecule
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