Passa al contenuto
Merck
Tutte le immagini(3)

Documenti

222569

Sigma-Aldrich

Fomepizole

99%

Sinonimo/i:

4-Methylpyrazole

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(3)

About This Item

Formula empirica (notazione di Hill):
C4H6N2
Numero CAS:
7554-65-6
Peso molecolare:
82.10
Beilstein:
105204
Numero CE:
231-445-0
Numero MDL:
MFCD00005245
Codice UNSPSC:
12352100
ID PubChem:
24853343
NACRES:
NA.22

Saggio

99%

Indice di rifrazione

n20/D 1.495 (lit.)

P. eboll.

99-100 °C/6 mmHg (lit.)

Solubilità

alcohol: soluble(lit.)
water: soluble(lit.)

Densità

0.993 g/mL at 25 °C (lit.)

Stringa SMILE

Cc1cn[nH]c1

InChI

1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
RIKMMFOAQPJVMX-UHFFFAOYSA-N

Informazioni sul gene

human ... ADH1A(124) , ADH1B(125) , ADH1C(126)

Cerchi prodotti simili? Visita Guida al confronto tra prodotti

Descrizione generale

4-Methylpyrazole inhibits CYP2E1 activity. It also acts as alcohol dehydrogenase inhibitor.

Applicazioni

Fomepizole (4-Methylpyrazole) can be used as:
  • A reactant to prepare 4-methyl-1-phenyl-1H-pyrazole by reacting with bromobenzene via N-arylation using a copper catalyst.
  • A starting material for the synthesis of 4-methyl-3(5)-nitropyrazole by nitration.
  • A ligand in the preparation of gallium(III) complex of 4-methylpyrazole as potential antitumor and antiviral agent.

Useful as an antidote in methanol and ethylene glycol poisoning.

Azioni biochim/fisiol

Alcohol dehydrogenase inhibitor
Alcohol dehydrogenase inhibitor.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H315,H319,H335

Classi di pericolo

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

204.8 °F - closed cup

Punto d’infiammabilità (°C)

96 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 6

1 of 6

GW6471 ≥98% (HPLC)

Sigma-Aldrich

G5045

GW6471

Disulfiram European Pharmacopoeia (EP) Reference Standard

D2950000

Disulfiram

Flufenamic acid analytical standard, for drug analysis

Supelco

F9005

Flufenamic acid

Sigma-Aldrich

Sigma-Aldrich

8.04604

Hydrazin hydrate (80% solution in water)

Sodium pyrophosphate tetrabasic ≥95%

Sigma-Aldrich

P8010

Sodium pyrophosphate tetrabasic

Auranofin ≥98% (HPLC)

Sigma-Aldrich

A6733

Auranofin

Jafar Shahraki et al.
Iranian journal of pharmaceutical research : IJPR, 12(4), 829-844 (2014-02-14)
In this research, we investigated the cytotoxic mechanisms of Cochlodinium polykrikoidescell lysate on isolated rat liver hepatocytes.This micro algae is responsible for a severe and widespread harmful algal bloom in the Persian Gulf and Gulf of Oman (2008-2009). Isolated hepatocytes
Marisa Battistella
The Annals of pharmacotherapy, 36(6), 1085-1089 (2002-05-23)
To assess the use of fomepizole in the treatment of ethylene glycol poisoning in the absence of hemodialysis. A MEDLINE search (1966-May 2001) of English-language literature pertaining to the use of fomepizole in ethylene glycol poisoning was performed. Key search
Samjhana Thapaliya et al.
Autophagy, 10(4), 677-690 (2014-02-05)
Patients with alcoholic cirrhosis and hepatitis have severe muscle loss. Since ethanol impairs skeletal muscle protein synthesis but does not increase ubiquitin proteasome-mediated proteolysis, we investigated whether alcohol-induced autophagy contributes to muscle loss. Autophagy induction was studied in: A) Human
Amanda M Barkley-Levenson et al.
Brain sciences, 11(1) (2021-01-23)
Central nervous system (CNS) hyperexcitability is a clinically significant feature of acute ethanol withdrawal. There is evidence for a genetic contribution to withdrawal severity, but specific genetic risk factors have not been identified. The gene glyoxalase 1 (Glo1) has been
J Samuelson et al.
Archives of medical research, 23(2), 31-33 (1992-01-01)
Ethanol is the major metabolic product of glucose fermentation by the protozoan parasite E. histolytica under the anaerobic conditions found in the lumen of the colon. With the goal of finding new targets for anti-amebic drugs, the E. histolytica NADP(+)-dependent
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.