218707
Cyclophosphamide monohydrate
≥98%
Sinonimo/i:
2-[Bis(2-chloroethyl)amino]tetrahydro-2H-1,3,2-oxazaphosphorine 2-oxide, Cytoxan
Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
About This Item
Formula empirica (notazione di Hill):
C7H15Cl2N2O2P · H2O
Numero CAS:
Peso molecolare:
279.10
Beilstein:
4678992
Numero CE:
Numero MDL:
Codice UNSPSC:
12352103
Prodotti consigliati
Saggio
≥98%
Punto di fusione
49-51 °C (lit.)
Stringa SMILE
[H]O[H].ClCCN(CCCl)P1(=O)NCCCO1
InChI
1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
PWOQRKCAHTVFLB-UHFFFAOYSA-N
Cerchi prodotti simili? Visita Guida al confronto tra prodotti
Azioni biochim/fisiol
Cyclophosphamide is a cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations. Its clinical activity is associated with a decrease in aldehyde dehydrogenase 1 (ALDH1) activity.
Cytotoxic nitrogen mustard derivative widely used in cancer chemotherapy. It cross-links DNA, causes strand breakage, and induces mutations.
Caratteristiche e vantaggi
Cancer research tool.
Sostituito da
N° Catalogo
Descrizione
Determinazione del prezzo
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Karen Gomez-Mariscal et al.
Annals of clinical and laboratory science, 48(2), 152-157 (2018-04-22)
The aim of the study was to determine if amniotic fluid cells of rats can be used to provide evidence of genotoxicity. In order to do that micronuclei formation was induced in rats during pregnancy after treatment with cyclophosphamide (CP)
Maria Bastaki et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 105, 278-284 (2017-04-30)
Tartrazine is approved as a food color additive internationally with INS number 102, in the United States as food color subject to batch certification "Food, Drug, and Cosmetic" (FD&C) Yellow No. 5, and in Europe as food color additive with
S Khan et al.
Toxicology international, 20(1), 68-76 (2013-07-09)
Recently, sodium valproate (VPA) has been proven as histone deacetylase (HDAC) inhibitor and potentiates the cytotoxicity of anticancer drugs, and also exhibit promising anti-cancer activity. Present study aimed to investigate the influence of pre- and post-treatment of VPA on cyclophosphamide
Marie Z Vasquez
Mutagenesis, 25(2), 187-199 (2009-12-09)
Despite regulatory directives requiring the reduction of animal use in safety testing, recent modifications to genotoxicity testing guidelines now propose the use of two in vivo genotoxicity assays as a follow-up to an in vitro positive (International Conference on Harmonization
Ricardo I Peraza-Vega et al.
Toxicology and industrial health, 33(5), 443-453 (2016-10-26)
The aim of this study was to evaluate the genotoxicity of the herbicide diuron in the wing-spot test and a novel wing imaginal disk comet assay in Drosophila melanogaster. The wing-spot test was performed with standard (ST) and high-bioactivation (HB)
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
Contatta l'Assistenza Tecnica.