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202096

Sigma-Aldrich

New Methylene Blue N zinc chloride double salt

Dye content 90 %

Sinonimo/i:

Basic blue 24, Methylene blue N

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About This Item

Formula empirica (notazione di Hill):
C18H22ClN3S · 0.5ZnCl2
Numero CAS:
Peso molecolare:
416.05
Colour Index:
52030
Numero CE:
Numero MDL:
Codice UNSPSC:
12171500
ID PubChem:
NACRES:
NA.47

Forma fisica

powder

Composizione

Dye content, 90%

Punto di fusione

>240 °C (dec.) (lit.)

λmax

591 nm
630 nm (2nd)

ε (coefficiente d’estinzione)

≥16000 at 242-248 nm in H2O
≥28000 at 284-290 nm in H2O
≥36000 at 588-594 nm in H2O
≥44000 at 629-635 nm in H2O

applicazioni

diagnostic assay manufacturing
hematology
histology

Temperatura di conservazione

room temp

Stringa SMILE

[Cl-].[Cl-].[Cl-].[Cl-].Cl[Zn]Cl.CCNc1cc2[s+]c3cc(NCC)c(C)cc3nc2cc1C.CCNc4cc5[s+]c6cc(NCC)c(C)cc6nc5cc4C

InChI

1S/2C18H22N3S.4ClH.Zn/c2*1-5-19-13-9-17-15(7-11(13)3)21-16-8-12(4)14(20-6-2)10-18(16)22-17;;;;;/h2*7-10,19-20H,5-6H2,1-4H3;4*1H;/q2*+1;;;;;+2/p-4
MCBJJSJOIVJYQY-UHFFFAOYSA-J

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Applicazioni

New Methylene Blue N zinc chloride double salt has been used as a photosensitizer for the in vitro photodynamic inactivation of plant-pathogenic fungi Colletotrichum acutatum and Colletotrichum gloeosporioides. It has also been used to determine the in vitro susceptibilities of Trichophyton mentagrophytes and Trichophyton rubrum microconidia to photodynamic antimicrobial chemotherapy (PACT).

Azioni biochim/fisiol

New Methylene Blue N zinc chloride double salt also known as methylene blue N is an azo dye. It can bind, neutralize and crosslink with RNA. This causes co-precipitation of ribosomal and residual RNA with the mitochondria and ferritin masses. These events make the living, young erythrocytes as microscopically visible, dark-blue clusters and filaments, referred to as reticulum. New Methylene Blue N zinc chloride double salt helps in counting of reticulocytes (erythrocytes containing RNA).

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves


Certificati d'analisi (COA)

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Mary Turgeon
Linne & Ringsrud's Clinical Laboratory Science (2011)
In Vitro Photodynamic Inactivation of Plant-Pathogenic Fungi Colletotrichum acutatum and Colletotrichum gloeosporioides with Novel Phenothiazinium Photosensitizers
de Menezes HD
Applied and Environmental Microbiology, 80, 1623-1632 (2014)
Susceptibilities of the dermatophytes Trichophyton mentagrophytes and T. rubrum microconidia to photodynamic antimicrobial chemotherapy with novel phenothiazinium photosensitizers and red light
Rodrigues GB
Journal of Photochemistry and Photobiology. B, Biology, 89-94 (2012)
PHOTODEGRADATION OF NEW METHYLENE BLUE N IN
AQUEOUS SOLUTION USING ZINC OXIDE AND
TITANIUM DIOXIDE AS CATALYST
ALI R
Jurnal Teknologi, 45, 31-42 (2006)
Gabriela Braga Rodrigues et al.
Journal of photochemistry and photobiology. B, Biology, 209, 111942-111942 (2020-07-06)
Antimicrobial photodynamic treatment (APDT) has emerged as an effective therapy against pathogenic fungi with both acquired and intrinsic resistance to commonly used antifungal agents. Success of APDT depends on the availability of effective photosensitizers capable of acting on different fungal

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