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Merck
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Documenti fondamentali

155306

Sigma-Aldrich

N1-(6-Indazolyl)sulfanilamide

98%

Sinonimo/i:

6-Sulfanilamidoindazole

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About This Item

Formula empirica (notazione di Hill):
C13H12N4O2S
Numero CAS:
Peso molecolare:
288.32
Numero CE:
Numero MDL:
Codice UNSPSC:
12352100
ID PubChem:
NACRES:
NA.22

Saggio

98%

Punto di fusione

193-195 °C (lit.)

Stringa SMILE

Nc1ccc(cc1)S(=O)(=O)Nc2ccc3cn[nH]c3c2

InChI

1S/C13H12N4O2S/c14-10-2-5-12(6-3-10)20(18,19)17-11-4-1-9-8-15-16-13(9)7-11/h1-8,17H,14H2,(H,15,16)
RLNLIVBLEZDLMZ-UHFFFAOYSA-N

Descrizione generale

N1-(6-Indazolyl)sulfanilamide ( 6-Sulfanilamidoindazole) causes inflammation in the hind paws and ankles of older rat and sensitizes them to the lethal action of endotoxin[1].

Pittogrammi

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Avvertenze

Warning

Indicazioni di pericolo

Classi di pericolo

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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R Hirschelmann et al.
International journal of tissue reactions, 8(6), 469-473 (1986-01-01)
Arthritis induced by 6-sulphanilamidoindazole in older rats is not inhibited by a one-week treatment with superoxide dismutase, peroxidase or desferrioxamine. It is concluded that oxygen radicals hardly play a special part in the pathogenesis of 6-SAI arthritis. C-reactive protein and
R Hirschelmann et al.
Agents and actions, 10(5), 431-434 (1980-11-01)
During 6-sulphanilamidoindazole (6-SAI) arthritis a significant increase of serum levels of the protease inhibitor alpha 2 macroglobulin (= alpha 2 acute phase globulin) and of Darcy's glycoprotein was found, whereas the content of female specific protein and of sulfhydryl groups
D D Blatter
Skeletal radiology, 16(3), 183-189 (1987-01-01)
Phosphorus-31 magnetic resonance spectroscopy (MRS) of the hind paws of rats was performed at 1.5 Tesla before and during the course of an experimentally-induced inflammatory arthritis. Arthritis was induced by daily subcutaneous administration of 6-sulfanilamidoindazole, an antibacterial sulfa known to
D Müller et al.
Agents and actions, 11(6-7), 736-740 (1981-12-01)
Hexobarbital sleeping time was prolonged and ethylmorphine N-demethylation was inhibited after a single dosage or seven administration of 6-SAI to old rats. These effects were independent of the development of arthritis. Changes in cytochrome P-450 concentration after 6-SAI treatment were
Y Ohmachi et al.
Histology and histopathology, 17(2), 437-444 (2002-04-19)
6-Sulfanilamidoindazole (6SAI) is known to induce not only an acute arthritis but also serositis and arteritis which resemble those induced by some vasodilators in rats. In this study, the recovery process of ankle lesions was examined histopathologically for up to

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