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Merck

ELANE

elastase, neutrophil expressed

Sinonimi:
ELA2, GE, HLE, HNE, NE, PMN-E, SCN1
Specie:
Human ELANE (1991), Mouse Elane (50701), Rat Elane (299606), sheep ELANE (101110841), cow ELANE (100126050), dog ELANE (442980), domestic cat ELANE (100301482), Horse ELANE (100462967), domestic guinea pig Elane (100724414)
ID UniProtKB:
P08246, P09649, Q6B0D9, Q6LDP5
ID gene:
  • Human(1991) Summary: Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq, May 2009]
  • Mouse(50701) elastase, neutrophil expressed
  • Rat(299606) elastase, neutrophil expressed
  • sheep(101110841) elastase, neutrophil expressed
  • cow(100126050) elastase, neutrophil expressed
  • dog(442980) elastase, neutrophil expressed
  • domestic cat(100301482) elastase, neutrophil expressed
  • Horse(100462967) elastase, neutrophil expressed
  • domestic guinea pig(100724414) elastase, neutrophil expressed

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Antibodies

N° Catalogo
Descrizione
Reattività con
Applicazione
MABS461
Anticorpo anti-elastasi neutrofila, clone AHN-10, clone AHN-10, from mouse,
Reattività con
human
Applicazione
immunocytochemistry
immunohistochemistry
immunoprecipitation (IP)
inhibition assay
radioimmunoassay
481001
Anti-Neutrophil Elastase Rabbit pAb, liquid, Calbiochem®,
Reattività con
human
Applicazione
SAB5500151
Anti-Neutrophil Elastase antibody, Rabbit monoclonal, clone SP203, recombinant, expressed in proprietary host, affinity isolated antibody,
Reattività con
human
Applicazione
immunohistochemistry
ZRB1927
Anti-Neutrophil Elastase Antibody, clone 1B2 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Reattività con
human
Applicazione
affinity binding assay
flow cytometry
immunocytochemistry
immunohistochemistry
western blot
HPA066836
Anti-ELANE antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Reattività con
human
Applicazione
immunohistochemistry

Proteins

N° Catalogo
Descrizione
Specie
E8140
Elastase from human leukocytes, lyophilized powder, ≥50 units/mg protein (Bradford),
Specie
human
A6150
α1-Antitrypsin from human plasma, salt-free, lyophilized powder,
Specie
human

esiRNA

N° Catalogo
Descrizione
Specie
EHU003711
MISSION® esiRNA, targeting human ELANE,
Specie
human