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T8931

Sigma-Aldrich

Thyrotropic hormone from bovine pituitary

Synonyme(s) :

TSH, Thyroid stimulating hormone, Thyrotropin from bovine pituitary glands

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About This Item

Numéro CAS:
Numéro MDL:
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32

Source biologique

bovine pituitary glands

Forme

powder

Conditionnement

vial of 100 μg

Technique(s)

cell culture | mammalian: suitable

Numéro d'accès UniProt

Température de stockage

2-8°C

Informations sur le gène

cow ... TSHB(281552)
human ... TSHR(7253)

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Description générale

Thyrotropin/thyroid-stimulating hormone (TSH) belongs to the glycoprotein hormone family. This glycoprotein is produced by thyrotroph cells of the anterior pituitary gland. It circulates in free form and possess a short plasma half-life.

Application

Thyrotropic hormone from bovine pituitary has been used:
  • to induce cAMP production in orbital fibroblasts.
  • as a component in Dulbecco modified eagle medium (DME) H-21:F-12 media.
  • for TSH stimulation test for assessing the thyroid gland function after nonthyroidal illness (NTI) induction.
  • for studying the thyrotropin involvement in photoperiodic signal transduction in mice.

Actions biochimiques/physiologiques

Thyrotropin/thyroid-stimulating hormone (TSH) helps to regulate thyroid function. In children, TSH plays a vital role in normal cognition and neurodevelopment. Circulating TSH is capable of binding to cell surface receptors in the thyroid gland. This hormone induces thyroid to produce thyroglobulin and the thyroid hormones. TSH can also promote the uptake of iodine (131I) in individuals with thyroid cancer. It can also enhance vascular endothelial growth factor (VEGF) secretion and angiogenesis in thyroid cancer cell lines.
Two-chain glycoprotein hormone. The α-chain is not active, biological specificity attributed rather to the β-chain. Activates adenylate cyclase in the thyroid gland, stimulating iodine uptake, thyroxine synthesis and release. Goitrogenic.

Qualité

Contains phosphate buffer salts

Code de la classe de stockage

11 - Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable


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Consulter la Bibliothèque de documents

Thyroid-stimulating hormone
The pituitary, 163-201 (2017)
Pituitary, Thyroid, and Parathyroid Pharmacology
Galasko GT
Pharmacology and Therapeutics for Dentistry, 417-428 (2017)
A small molecule antagonist inhibits thyrotropin receptor antibody-induced orbital fibroblast functions involved in the pathogenesis of Graves ophthalmopathy
Turcu AF, et al.
The Journal of Clinical Endocrinology and Metabolism, 98(5), 2153-2159 (2013)
Concentration of thyrotropic hormone in persons occupationally exposed to lead, cadmium and arsenic
Jurdziak M, et al.
Biological trace element research, 182(2), 196-203 (2018)
Roberto Rocchi et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(14), 6019-6024 (2007-03-29)
Bacterial infections and other pathologic conditions induce complex dysfunctions of the hypothalamic-pituitary-thyroid axis, collectively known as nonthyroidal illness (NTI). To explore the pathogenesis of bacterial NTI, we injected Mycobacterium tuberculosis extracts or Escherichia coli LPS in mice lacking key components

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