T2877

3,3′,5-Triiodo-L-thyronine

≥95% (HPLC), powder

• Synonyme(s) : O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine, Liothyronine, T₃
• Formule empirique (notation de Hill): C₁₅H₁₂I₃NO₄
• Numéro CAS: 6893-02-3
• Poids moléculaire : 650.97
• Beilstein: 2710227
• Numéro CE : 229-999-3
• Numéro MDL: MFCD00002593
• Code UNSPSC : 51111800
• ID de substance PubChem : 24900088
• Nomenclature NACRES : NA.32
• Source biologique: synthetic (organic)
• Forme: powder
• Essai: ≥95% (HPLC)

Propriétés

• Source biologique: synthetic (organic)
• Niveau de qualité: 200
• Stérilité: non-sterile
• Essai: ≥95% (HPLC)
• Forme: powder
• Activité optique: [α]25/D +23.0°, c = 2 in 1 N HCl: ethanol, 1:2
• Technique(s): transfection: suitable
• Pf: 234-238 °C (lit.)
• Solubilité: 4 M NH₄OH in methanol: 5 mg/mL, clear to very slightly hazy, colorless to light yellow
• Conditions d'expédition: ambient
• Température de stockage: −20°C
• Chaîne SMILES: N[C@@H](Cc1cc(I)c(Oc2ccc(O)c(I)c2)c(I)c1)C(O)=O
• InChI: 1S/C15H12I3NO4/c16-9-6-8(1-2-13(9)20)23-14-10(17)3-7(4-11(14)18)5-12(19)15(21)22/h1-4,6,12,20H,5,19H2,(H,21,22)/t12-/m0/s1
• Clé InChI: AUYYCJSJGJYCDS-LBPRGKRZSA-N
• Informations sur le gène: human ... THRA(7067) , THRB(7068) ; rat ... Thra(81812) , Thrb(24831)

Description

Application

3,3′,5-Triiodo-L-thyronine can be used for Insulin-like growth factor I assays performed by using a double antibody radioimmunoassay.[1] The product can also be used for in vitro transfection of 293T cells.[2]

Actions biochimiques/physiologiques

3,3′,5-Triiodo-L-thyronine also referred to as O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine or T3 is the biologically active thyroid hormone. In hypothyroidism pateints, triiodothyronine enhances mood and neuropsychological function.[3] The product also positively regulates the hepatic FGF21 expression[2] and stimulates the metabolic breakdown of glucose, fats, and proteins by enhancing the levels of numerous metabolic enzymes such as hexokinase, liver glucose 6-phosphatase as well as mitochondrial enzymes for oxidative phosphorylation. Additionally, the product facilitates the normal body growth in children and is pivotal for central nervous system maturation in foetus.

Notes préparatoires

3,3′,5-Triiodo-L-thyronine dissolves in 4M NH4OH in MeOH at 5 mg/ml to yield a colorless to light yellow, clear to very slightly hazy solution.

Autres remarques

This product has not been tested for cell culture. A sterile version is offered that is suitable for cell culture. The T5516 is a sterile preparation that is cell culture tested. Please review the product page for product T2877

Informations sur la sécurité

• Pictogrammes: GHS08
• Mention d'avertissement: Danger
• Mentions de danger: H372
• Conseils de prudence: P260 - P264 - P270 - P314 - P501
• Classification des risques: STOT RE 1
• Organes cibles: Thyroid,Cardio-vascular system,Kidney
• Code de la classe de stockage: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable
• Équipement de protection individuelle: dust mask type N95 (US), Eyeshields, Gloves