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T8024

Sigma-Aldrich

Tetrodotoxin

≥98% (HPLC), powder

Synonyme(s) :

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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About This Item

Formule empirique (notation de Hill):
C11H17N3O8
Numéro CAS:
4368-28-9
Poids moléculaire :
319.27
Numéro Beilstein :
49176
Numéro CE :
224-458-8
Numéro MDL:
MFCD00213719
Code UNSPSC :
12352200
ID de substance PubChem :
24900493

Pureté

≥98% (HPLC)

Forme

powder

Couleur

white

Solubilité

dilute citrate or acetate buffer: 1 mg/mL (dissolve at pH 4-5. Aqueous solutions, pH 4-5, are stable if stored frozen.)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

Température de stockage

2-8°C

Chaîne SMILES 

[H][C@]12OC3(O)OC(C4[C@@H](O)NC(=N)NC4([C@@H]1O)[C@@H]3O)[C@@]2(O)CO

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

Clé InChI

CFMYXEVWODSLAX-IXUBDLNJSA-N

Informations sur le gène

rat ... Scnn1g(24768)

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Application

Tetrodotoxin has been used as standard during HPLC-based analysis of biotoxins from P. punctata tentacles whole crude extract (PHY-N). Tetrodotoxin has also been used to study its effects on low-threshold transient (LTT) Ca2+ currents in rat hippocampal interneurons.

Actions biochimiques/physiologiques

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Notes préparatoires

Tetrodotoxin is soluble in dilute citrate or acetate buffer at 1 mg/ml (pH 4-5). Aqueous solutions are stable at pH 4-5 if stored frozen. However, tetrodotoxin is unstable in strong acid or alkaline solutions and is destroyed by boiling at pH2.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H300

Conseils de prudence

P301 + P330 + P331 + P310

Classification des risques

Acute Tox. 1 Oral

Code de la classe de stockage

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Équipement de protection individuelle

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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