T7204

Toremifene citrate salt

≥98% (HPLC)

• Synonyme(s) : (Z)-2-(4-(4-Chloro-1,2-diphenyl-1-butenyl)phenoxy)-N,N-dimethylethanamine, Acapodene, Fareston, GTx 006, Z-Toremifene
• Formule empirique (notation de Hill) : C₂₆H₂₈ClNO · C₆H₈O₇
• Numéro CAS: 89778-27-8
• Poids moléculaire : 598.08
• Numéro MDL: MFCD01729016
• Code UNSPSC : 51111800
• ID de substance PubChem : 329826860
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to off-white
• Solubilité: DMSO: >10 mg/mL
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(=O)CC(O)(CC(O)=O)C(O)=O.CN(C)CCOc1ccc(cc1)C(=C(\CCCl)c2ccccc2)\c3ccccc3
• InChI: 1S/C26H28ClNO.C6H8O7/c1-28(2)19-20-29-24-15-13-23(14-16-24)26(22-11-7-4-8-12-22)25(17-18-27)21-9-5-3-6-10-21;7-3(8)1-6(13,5(11)12)2-4(9)10/h3-16H,17-20H2,1-2H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-;
• Clé InChI: IWEQQRMGNVVKQW-OQKDUQJOSA-N
• Informations sur le gène: human ... ESR1(2099) , ESR2(2100)

Description

Description générale

Toremifene is a triphenylethylene derivative.[1] It exhibits antitumor and antiestrogen effects.[2] Toremifene has estrogen-agonist effects on blood lipids and endometrium.[3]

Application

Toremifene citrate salt has been used:

• in cell-based ELISA[4]
• as a positive control to detect its antiviral activity against Ebola virus (EBOV)[5]
• to treat MCF7 and T47D breast cancer cell lines[6]

Actions biochimiques/physiologiques

Toremifene citrate is an oral selective estrogen receptor modulator (SERM). It is used in advanced (metastatic) breast cancer and being evaluated for prevention of prostate cancer. Toremifene citrate is known to increase bone mineral density in prostate cancer patients undergoing androgen deprivation therapy†.

Caractéristiques et avantages

This compound is featured on the Nuclear Receptors (Steroids) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Notes préparatoires

Toremifene citrate salt is soluble in DMSO at a concentration that is greater than 10 mg/ml.

Informations sur la sécurité

• Pictogrammes: GHS05,GHS07,GHS09
• Mention d'avertissement: Danger
• Mentions de danger: H302,H318,H410
• Conseils de prudence: P264 - P273 - P280 - P301 + P312 - P305 + P351 + P338 - P391
• Classification des risques: Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1
• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable