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T5651

Sigma-Aldrich

Tetrodotoxin with Citrate Buffer

pH 4.8, powder

Synonyme(s) :

Fugu poison, Maculotoxin, TTX, Tarichatoxin

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About This Item

Formule empirique (notation de Hill):
C11H17N3O8
Numéro CAS:
4368-28-9
Poids moléculaire :
319.27
Numéro Beilstein :
49176
Numéro MDL:
MFCD00213719
Code UNSPSC :
12352200
ID de substance PubChem :
24900308

Forme

powder

Disponibilité

not available in USA

pH

4.8

Solubilité

H2O: soluble (stable at pH 4-5 if stored frozen)
strong acid or alkaline solutions: unstable (destroyed by boiling at pH 2.)

Température de stockage

2-8°C

Chaîne SMILES 

OC[C@@]1(O)[C@H]2OC3(O)OC1C4[C@@H](O)NC(=N)NC4([C@@H]2O)[C@@H]3O

InChI

1S/C11H17N3O8/c12-8-13-6(17)2-4-9(19,1-15)5-3(16)10(2,14-8)7(18)11(20,21-4)22-5/h2-7,15-20H,1H2,(H3,12,13,14)/t2?,3-,4?,5+,6-,7+,9+,10?,11?/m1/s1

Clé InChI

CFMYXEVWODSLAX-IXUBDLNJSA-N

Informations sur le gène

rat ... Scnn1g(24768)

Application

Tetrodotoxin has been used to study its effects on microglial functions in rats2. This toxin has also been used to inactivate lateral magnocellular nucleus of the nidopallium (LMAN) in juvenile zebra finch. This study reported that the toxin causes a decrease in sequence and acoustic variability which result in the production of a stereotyped song by the motor pathway3.

Actions biochimiques/physiologiques

Reversible, selective blocker of Na+ channels; blocks propagation of impulses in excitable membranes. Used to characterize sodium channels in excitable membranes and to study the role of sodium channels in normal physiology and disease.

Conditionnement

Vial contains 1 mg of tetrodotoxin and approx. 5 mg citrate buffer, pH 4.8.

Notes préparatoires

The product is water soluble and stable at pH 4-5 if it is stored frozen. It is unstable in strong acid and alkaline solutions and is rapidly destroyed by boiling at pH 2 and below.

Pictogrammes

Skull and crossbones
GHS06

Mention d'avertissement

Danger

Mentions de danger

H300

Conseils de prudence

P301 + P330 + P331 + P310

Classification des risques

Acute Tox. 1 Oral

Code de la classe de stockage

6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

Certificats d'analyse (COA)

Recherchez un Certificats d'analyse (COA) en saisissant le numéro de lot du produit. Les numéros de lot figurent sur l'étiquette du produit après les mots "Lot" ou "Batch".

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Consulter la Bibliothèque de documents

Thomas C Jaramillo et al.
Autism research : official journal of the International Society for Autism Research, 10(1), 42-65 (2016-08-06)
Mutations/deletions in the SHANK3 gene are associated with autism spectrum disorders and intellectual disability. Here, we present electrophysiological and behavioral consequences in novel heterozygous and homozygous mice with a transcriptional stop cassette inserted upstream of the PDZ domain-coding exons in
Miriam Michel et al.
Scientific reports, 9(1), 11888-11888 (2019-08-17)
Assessment of left ventricular mass (LVM) is important in the evaluation of patients with congenital heart disease (CHD) and cardiac magnetic resonance imaging (CMR) is the gold standard. Recent software allows LVM calculation by real-time 3-dimensional echocardiography (RT3DE). We investigated
Hao Yang et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 27(8), 1467-1482 (2019-06-04)
Irreversible neuron loss following spinal cord injury (SCI) usually results in persistent neurological dysfunction. The generation of autologous neural stem cells (NSCs) holds great potential for neural replenishment therapies and drug screening in SCI. Our recent studies demonstrated that mature
Scott R Burks et al.
Theranostics, 9(19), 5517-5531 (2019-09-20)
Pulsed focused ultrasound (pFUS) technology is being developed for clinical neuro/immune modulation and regenerative medicine. Biological signal transduction of pFUS forces can require mechanosensitive or voltage-gated plasma membrane ion channels. Previous studies suggested pFUS is capable of activating either channel
Jie Zhang et al.
Acta biochimica et biophysica Sinica, 51(6), 562-570 (2019-05-30)
The protein voltage-gated sodium channel Nav1.5 is highly upregulated in various types of cancer and, in general, promotes cancer cell invasiveness and metastatic progression. A previous study found that Nav1.5 was highly expressed in poorly differentiated oral squamous cell carcinoma
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