SRP8026

Annexin V human

recombinant, expressed in E. coli, GST tagged, ≥95% (SDS-PAGE)

• Synonyme(s) : Annexin A5, Calphobindin I, EC 2.7.1.23, Endonexin II, Placental anticoagulantprotein I
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.32

Propriétés

• Source biologique: human
• Produit recombinant: expressed in E. coli
• Étiquette/Marqueur: GST tagged
• Essai: ≥95% (SDS-PAGE)
• Forme: lyophilized
• Poids mol.: ~52 kDa
• Conditionnement: pkg of 100 μg
• Conditions de stockage: avoid repeated freeze/thaw cycles
• Technique(s): activity assay: suitable
• Couleur: white
• Numéro d'accès UniProt: P08758
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Informations sur le gène: human ... ANXA5(308)

Description

Description générale

Annexin V is a member of the annexin family of calcium and membrane-binding proteins that have anticoagulatory and anti-inflammatory properties. The encoded protein is 320 amino acid long and is folded into four domains, each having five α-helices, forming a superhelical globular structure. The ANX5 gene is mapped to human chromosome 4q26-q28 and spans a length of 28kb containing 13 exons and 12 introns.[1][2]

Application

Annexin V has been used to examine phosphorylation activity of ChaK1 (channel-kinase 1).[3]

Actions biochimiques/physiologiques

Annexins are a family of water-soluble proteins that bind to membranes and phospholipids in a calcium-dependent manner. They participate in several cellular functions, such as membrane fusion and cytoskeletal interaction. Annexin V is a potent anticoagulant and serves as a voltage-gated calcium channel when bound to membrane in vitro. It is found to inhibit phospholipase A2 and protein kinase C.[1][2][4]

Forme physique

Lyophilized from PBS, pH 7.4.

Reconstitution

Reconstitute with 100 μL deionized water.

Autres remarques

Recombinant human annexin V fused to a GST-tag.

Informations sur la sécurité

• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable