SRP3064
IGF-Binding Protein 4 human
recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonyme(s) :
HT29-IGF-BP, IBP-4, colon cancer cell growth inhibitor
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20 μG
321.00 CHF
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20 μG
321.00 CHF
About This Item
Code UNSPSC :
51111800
Nomenclature NACRES :
NA.32
Produits recommandés
Source biologique
human
Produit recombinant
expressed in (BTI-Tn-5B1-4) High-5 Insect Cells
Essai
≥98% (HPLC)
≥98% (SDS-PAGE)
Forme
lyophilized
Poids mol.
25.8 kDa
Conditionnement
pkg of 20 μg
Technique(s)
cell culture | mammalian: suitable
Impuretés
<0.1 EU/μg endotoxin, tested
Couleur
white to off-white
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Informations sur le gène
human ... IGFBP4(3487)
Description générale
The gene IGFBP4 (insulin-like growth factor-binding protein 4) is mapped to human chromosome 17q21.[1] It belongs to the IGFBP family of proteins. The protein has a IGF (insulin-like growth factor)-binding site and a thyroglobulin type-1 domain. IGFBPs are mainly required to regulate IGFs activities.[2] IGFBP4 can be cleaved by PAPP-A (pregnancy-associated plasma protein-A) in IGF-dependent mechanism.[3]
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Recombinant human IGF-BP4 is a 25.7kDa protein consisting of 237 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.
Application
IGF-Binding Protein 4 human has been used to check the dependency of FSH (follicle-stimulating hormone) action in human Cumulus granulosa cells on IGF-2 (insulin-like growth factor 2).[4]
Actions biochimiques/physiologiques
IGFBP4 (insulin-like growth factor-binding protein 4) suppresses cell proliferation and DNA synthesis and induces cell death.[5] IGFBP4 participates in adipose tissue expandability and interacts with IGF1 (insulin-like growth factor 1). Interaction with IGF1 disrupts mitogenic signaling.[6] IGFBP4 is suggested as a serum biomarker of Lupus Nephritis and is associated with the chronicity of renal pathology in patients.[7] IGFBP4 is also linked with cardiovascular death in type 1 diabetes patients in the absence/presence of nephropathy.[8] It is also linked with the progression of tumors.[2]
Séquence
DEAIHCPPCS EEKLARCRPP VGCEELVREP GCGCCATCAL GLGMPCGVYT PRCGSGLRCY PPRGVEKPLH TLMHGQGVCM ELAEIEAIQE SLQPSDKDEG DHPNNSFSPC SAHDRRCLQK HFAKIRDRST SGGKMKVNGA PREDARPVPQ GSCQSELHRA LERLAASQSR THEDLYIIPI PNCDRNGNFH PKQCHPALDG QRGKCWCVDR KTGVKLPGGL EPKGELDCHQ LADSFRE
Forme physique
Lyophilized from 1x PBS, pH 7.2.
Reconstitution
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Code de la classe de stockage
11 - Combustible Solids
Classe de danger pour l'eau (WGK)
WGK 3
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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A J Ryan et al.
British journal of cancer, 101(2), 278-286 (2009-06-19)
Insulin-like growth factor 1 (IGF1) promotes breast cancer and disease progression. Bioavailability of IGF1 is modulated by IGF-binding proteins (IGFBPs). IGFBP4 inhibits IGF1 activity but cleavage by pregnancy-associated plasma protein-A (PAPP-A) protease releases active IGF1. Expression of IGF pathway components
P M Schiltz et al.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 8(4), 391-396 (1993-04-01)
This laboratory has purified a unique insulin-like growth factor binding protein (IGFBP-4) that was previously demonstrated to be inhibitory to bone cell proliferation. In this study, the hypothesis that IGFBP-4 is inhibitory to insulin-like growth factor (IGF) actions on cartilage
Gene expression profiles in asbestos-exposed epithelial and mesothelial lung cell lines.
Nymark P, et al.
BMC Genomics, 8, 62-62 (2007)
FSH Regulates IGF-2 Expression in Human Granulosa Cells in an AKT-Dependent Manner.
Baumgarten SC, et al.
The Journal of Clinical Endocrinology and Metabolism, 100, E1046-E1046 (2015)
Control of adipose tissue expandability in response to high fat diet by the insulin-like growth factor-binding protein-4.
Gealekman O, et al.
The Journal of Biological Chemistry, 289, 18327-18327 (2014)
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