Nuclear receptors form the largest known family of transcription factors and have a crucial role in nearly all aspects of vertebrate development and adult physiology by transducing the effects of hormones into transcriptional responses. The family is defined by two domains: (a) the central, highly conserved, DNA-binding domain (DBD) of approx. 66 amino acids, and (b) the C-terminal, structurally conserved, ligand-binding domain (LBD) of approx. 250 amino acids. The amino-terminal regions are least conserved among nuclear receptor sequences. Retinoids, the natural and syntheic derivatives of vitamin A, have been shown to inhibit the growth of many human tumor cells. Although the exact mechanism for this growth suppression remains unknown, the importance of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) have been established in a number of tumor cell models. Three types of RARs have been identified (RAR, RAR, and RAR ) with homologous but slightly different retinoic acid (RA) binding domains. Transactivation assays and retinoid binding assays with RAR, RAR, and RAR have shown that each RAR has a different affinity for RA and RA analogs.
Forme physique
Clear and colorless frozen liquid solution
Notes préparatoires
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.
Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
Faites votre choix parmi les versions les plus récentes :
Trends in biochemical sciences, 17(10), 427-433 (1992-10-01)
Complexity in the retinoid signalling system arises from a combination of several forms of retinoic acid, multiple cytoplasmic binding proteins and nuclear receptors, and the existence of polymorphic retinoic acid response elements. Additional diversity appears to be generated by heterodimeric
Nonsteroid nuclear receptors: what are genetic studies telling us about their role in real life?
P Kastner et al.
Cell, 83(6), 859-869 (1995-12-15)
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