MLL1/WAR complex of human MLL1 (GenBank Accession No. NM_005933), amino acids 3745- end with N-terminal His-tag, MW= 27 kDa, human Ash2L (GenBank Accession No. NM_001105214), amino acids 2-end with N-terminal His-tag, MW= 61 kDa, and human RbBP5 (GenBank Accession No. NM_005057), amino acids 2-end with N-terminal His-tag, MW= 60 kDa, individually expressed in an E. coli expression system, and human WDR5 (GenBank Accession No. NM_017588), amino acids 2-end with N-terminal His-tag, MW= 37.4 kDa expressed in a Baculovirus Sf9 expression system.
The RNA polymerase II (Pol II) elongation factor (ELL) was the first translocation partner of mixed lineage leukaemia (MLL) for which a biochemical function was determined. It was therefore proposed that the regulation of the elongation stage of transcription could
The Journal of biological chemistry, 284(36), 24242-24256 (2009-06-27)
Transcription in eukaryotic genomes depends on enzymes that regulate the degree of histone H3 lysine 4 (H3K4) methylation. The mixed lineage leukemia protein-1 (MLL1) is a member of the SET1 family of H3K4 methyltransferases and is frequently rearranged in acute
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