SML1784

BTI-A-404

≥98% (HPLC)

• Synonyme(s) : 4-[4-(Dimethylamino)phenyl]-N-(3,5-dimethylphenyl)-1,2,3,4-tetrahydro-6-methyl-2-oxo-5-pyrimidinecarboxamide
• Formule empirique (notation de Hill): C₂₂H₂₆N₄O₂
• Numéro CAS: 537679-57-5
• Poids moléculaire : 378.47
• Code UNSPSC : 51111800
• ID de substance PubChem : 329826063
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Température de stockage: 2-8°C
• Chaîne SMILES: O=C1NC(C2=CC=C(N(C)C)C=C2)C(C(NC3=CC(C)=CC(C)=C3)=O)=C(C)N1
• Clé InChI: JQVNMIXFWKEYQJ-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

BTI-A-404 is a potent and selective competitive inverse agonist of human GPR43 (FFAR2).

BTI-A-404 is a potent and selective competitive inverse agonist of human GPR43 (GPR43/Free Fatty Acid Receptor 2, FFAR2) that increases the cyclic AMP level and regulates and reduces acetate-induced cytoplasmic Ca²⁺ level. BTI-A-404 regulates the downstream signaling pathways of GPR43, including ERK, p38 MAPK, and NF-KB. BTI-A-404 stimulates GLP-1 release.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable