SML1711

TNCA

≥98% (HPLC)

• Synonyme(s) : (3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid, L-1,2,3,4-Tetrahydronorharman-3-carboxylic acid, Lycoperodine-1
• Formule empirique (notation de Hill) : C₁₂H₁₂N₂O₂
• Numéro CAS: 42438-90-4
• Poids moléculaire : 216.24
• Numéro MDL: MFCD00272641
• Code UNSPSC : 12352200
• ID de substance PubChem : 329826033
• Nomenclature NACRES : NA.77

Propriétés

• Niveau de qualité: 100
• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1))
• Couleur: white to beige
• Solubilité: 1.5 mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed)
• Température de stockage: −20°C
• Chaîne SMILES: O=C(O)[C@H]1NCC2=C(C3=C(N2)C=CC=C3)C1
• InChI: 1S/C12H12N2O2/c15-12(16)10-5-8-7-3-1-2-4-9(7)14-11(8)6-13-10/h1-4,10,13-14H,5-6H2,(H,15,16)/t10-/m0/s1
• Clé InChI: FSNCEEGOMTYXKY-JTQLQIEISA-N

Description

Actions biochimiques/physiologiques

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity.

TNCA is a tryptophan derivative that binds the parathyroid Ca²⁺-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable