SML1320

NSC687852

≥98% (HPLC)

• Synonyme(s) : (3E,5E)-1-Acryloyl-3,5-bis(4-nitrobenzylidene)piperidin-4-one, 3,5-Bis((4-nitrophenyl)methylidene)-1-prop-2-enoylpiperidin-4-one, b-AP15
• Formule empirique (notation de Hill): C₂₂H₁₇N₃O₆
• Numéro CAS: 330450-45-8
• Poids moléculaire : 419.39
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825783
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: protect from light
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL, clear (warmed)
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Chaîne SMILES: O=C(C(CN(C(C=C)=O)C1)=CC2=CC=C([N+]([O-])=O)C=C2)C1=CC3=CC=C([N+]([O-])=O)C=C3
• InChI: 1S/C22H17N3O6/c1-2-21(26)23-13-17(11-15-3-7-19(8-4-15)24(28)29)22(27)18(14-23)12-16-5-9-20(10-6-16)25(30)31/h2-12H,1,13-14H2
• Clé InChI: GFARQYQBWJLZMW-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

NSC687852 is a cell-permeable, potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitinases (DUBs) UCHL5 and USP14, with no effect on UCH-L1, UCH-L3, USP2, USP7, USP8 and BAP1 and on the proteasomal proteolytic activities. NSC687852 induces cell-cycle arrest and apoptosis in several colon cancers and in CNS cells, and suppresses tumor growth in various mouse models.

NSC687852 is a cell-permeable, potent, reversible and selective inhibitor of 19S regulatory-particle-associated deubiquitinases (DUBs) UCHL5 and USP14.

Autres remarques

Light and air sensitive.

Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H302,H317
• Conseils de prudence: P280 - P301 + P312 + P330 - P333 + P313
• Classification des risques: Acute Tox. 4 Oral - Skin Sens. 1
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable