SML0968

Y11

≥98% (HPLC)

• Synonyme(s) : 1-(2-Hydroxyethyl)-3,5,7-Triaza-1-azoniatricyclo[3.3.1.13,7]decane bromide, NSC206142
• Formule empirique (notation de Hill) : C₈H₁₇N₄O · Br
• Numéro CAS: 1086639-59-9
• Poids moléculaire : 265.15
• Code UNSPSC : 12352200
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: H₂O: 25 mg/mL, clear
• Température de stockage: −20°C

Description

Actions biochimiques/physiologiques

Y11 inhibits the activity of focal adhesion kinase (FAK) by binding to the amino-terminal domain of FAK and blocking autophosphorylation of tyrosine residue Y397. Y11 inhibits the viability of SW620 and BT474 cancer cell lines and significantly reduces tumor volume in mouse xenografts.

Y11 inhibits the activity of focal adhesion kinase (FAK).

Y11 has high cytotoxic effects with IC₅₀ values ranging from 3.87 to 4.66 mM, against non-small cell lung carcinoma (NSCLC) A549 cells. It plays a major role in the protein structures across the kunitz protein domain of viperids and elapids.

Caractéristiques et avantages

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Informations sur la sécurité

• Pictogrammes: GHS07
• Mention d'avertissement: Warning
• Mentions de danger: H315,H319,H335
• Conseils de prudence: P261 - P305 + P351 + P338
• Classification des risques: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Organes cibles: Respiratory system
• Code de la classe de stockage: 13 - Non Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable