SML0445

Clemastine fumarate salt

≥98% (HPLC)

• Synonyme(s) : (+)-2-[2-[(p-Chloro-α-methyl-α-phenylbenzyl)oxy]ethyl]-1-methylpyrrolidine fumarate salt, (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine fumarate salt, 1-Methyl-2-[2-(α-methyl-p-chlorobenzhydryloxy)ethyl]pyrrolidine fumarate salt, 1-Methyl-2-[2-(methyl-p-chlorodiphenylmethyloxy)ethyl]pyrrolidine fumarate salt, Meclastine fumarate salt, Mecloprodine
• Formule empirique (notation de Hill) : C₂₁H₂₆ClNO · C₄H₄O₄
• Numéro CAS: 14976-57-9
• Poids moléculaire : 459.96
• Numéro CE : 239-055-2
• Numéro MDL: MFCD00137486
• Code UNSPSC : 12352200
• ID de substance PubChem : 329824727
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥98% (HPLC)
• Forme: powder
• Activité optique: [α]/D +15 to +25°, c = 1 in methanol
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL (clear solution; warmed)
• Température de stockage: room temp
• Chaîne SMILES: OC(=O)\C=C\C(O)=O.CN1CCC[C@@H]1CCO[C@](C)(c2ccccc2)c3ccc(Cl)cc3
• InChI: 1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1
• Clé InChI: PMGQWSIVQFOFOQ-YKVZVUFRSA-N
• Informations sur le gène: human ... HRH1(3269)

Description

Description générale

Clemastine fumarate is used to treat multiple sclerosis,[1] sneezing and rhinorrhea linked to common cold.[2] It stimulates oligodendrocyte progenitor cell (OPC) differentiation and myelination.[1]

Application

Clemastine fumarate salt has been used as a stimulator of rodent oligodendrocyte generation and myelination in vitro and in vivo.[3]

Actions biochimiques/physiologiques

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic that also has antipruritic activity.

Clemastine fumarate is an antihistamine H1-antagonist and anticholinergic.

Caractéristiques et avantages

This compound is featured on the Histamine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable