SML0396

Tafenoquine succinate

≥95% (HPLC)

• Synonyme(s) : N-[2,6-Dimethoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]quinolin-8-yl]pentane-1,4-diamine, SB-252263, WR 238605
• Formule empirique (notation de Hill) : C₂₄H₂₈F₃N₃O₃ · C₄H₆O₄
• Numéro CAS: 106635-81-8
• Poids moléculaire : 581.58
• Numéro MDL: MFCD00892249
• Code UNSPSC : 12352200
• ID de substance PubChem : 329825392
• Nomenclature NACRES : NA.77

Propriétés

• Essai: ≥95% (HPLC)
• Forme: powder
• Conditions de stockage: desiccated
• Couleur: white to beige
• Solubilité: DMSO: 5 mg/mL (clear solution)
• Température de stockage: 2-8°C
• Chaîne SMILES: OC(=O)CCC(O)=O.COc1cc(C)c2c(Oc3cccc(c3)C(F)(F)F)c(OC)cc(NC(C)CCCN)c2n1
• InChI: 1S/C24H28F3N3O3.C4H6O4/c1-14-11-20(32-4)30-22-18(29-15(2)7-6-10-28)13-19(31-3)23(21(14)22)33-17-9-5-8-16(12-17)24(25,26)27;5-3(6)1-2-4(7)8/h5,8-9,11-13,15,29H,6-7,10,28H2,1-4H3;1-2H2,(H,5,6)(H,7,8)
• Clé InChI: CQBKFGJRAOXYIP-UHFFFAOYSA-N

Description

Actions biochimiques/physiologiques

Tafenoquine has been generally generated for oral administration and drug absorption increases when taken along with food.[1] It is known to possess a longer half life.[2]

Tafenoquine is an antimalarial primaquine analog being investigated to treat and prevent Plasmodium vivax infections. It can eliminate both blood and liver stages of Plasmodium vivax. Tafenoquine has also been tested as a therapy for leishmaniasis.

Tafenoquine is an antimalarial.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable