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SML0258

Sigma-Aldrich

CPPG

≥98% (HPLC)

Synonyme(s) :

(R,S)-α-Cyclopropyl-4-phosphonophenylglycine

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About This Item

Formule empirique (notation de Hill):
C11H14NO5P
Numéro CAS:
183364-82-1
Poids moléculaire :
271.21
Numéro MDL:
MFCD00673967
Code UNSPSC :
12352200
ID de substance PubChem :
329825266
Nomenclature NACRES :
NA.77

Essai

≥98% (HPLC)

Forme

powder

Conditions de stockage

desiccated

Couleur

white to beige

Solubilité

H2O: >5 mg/mL

Température de stockage

room temp

Chaîne SMILES 

NC(C1CC1)(C(O)=O)c2ccc(cc2)P(O)(O)=O

InChI

1S/C11H14NO5P/c12-11(10(13)14,7-1-2-7)8-3-5-9(6-4-8)18(15,16)17/h3-7H,1-2,12H2,(H,13,14)(H2,15,16,17)

Clé InChI

IGODGTDUQSMDQU-UHFFFAOYSA-N

Actions biochimiques/physiologiques

(R,S)-α-Cyclopropyl-4-phosphonophenylglycine (CPPG) can be used in combination with scopolamine to treat the depressive disorder.[1]
CPPG is a potent group II/III metabotropic glutamate receptor antagonist, with approximately 20-fold selectivity for mGlu group III over group II (IC50 values of 2.2 and 46.2 nM respectively).
CPPG is a potent group II/III metabotropic glutamate receptor antagonist.

Caractéristiques et avantages

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Pictogrammes

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GHS07

Mention d'avertissement

Warning

Mentions de danger

H302

Classification des risques

Acute Tox. 4 Oral

Code de la classe de stockage

13 - Non Combustible Solids

Classe de danger pour l'eau (WGK)

WGK 3

Point d'éclair (°F)

Not applicable

Point d'éclair (°C)

Not applicable

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Certificats d'analyse (COA)

Lot/Batch Number
042M4752V

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Kouji Fukuyama et al.
Biomolecules, 9(6) (2019-06-20)
Pharmacological mechanisms of gold-standard antipsychotics against treatment-refractory schizophrenia, such as clozapine (CLZ), remain unclear. We aimed to explore the mechanisms of CLZ by investigating the effects of MK801 and CLZ on tripartite synaptic transmission in the thalamocortical glutamatergic pathway using
Mohaddeseh Ebrahimi-Ghiri et al.
Physiology & behavior, 224, 113034-113034 (2020-07-01)
Clinical trials have revealed that the muscarinic receptor antagonist scopolamine produces a fast and potent antidepressant response. However, the anticholinergic adverse effects and the risk of psychosis at higher doses limit the widespread clinical use of scopolamine. Combination therapy of
Xing Yang et al.
Frontiers in bioengineering and biotechnology, 8, 903-903 (2020-10-30)
A simple and facile one-step method was developed to construct a small molecular prodrug amphiphile self-assembled organic dots CPPG with aggregation-induced emission (AIE) characteristics. Diphenylalanine peptide (FF), which is the essential moiety of the self-assembling peptide-drug conjugate and as its
Gelareh Abulwerdi et al.
Neurochemistry international, 138, 104770-104770 (2020-05-27)
Chronic dysregulated microglial activation may lead to persistent inflammation and progressive neurodegeneration. A previous study reported that ADX88178, a putative metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM), exerts anti-inflammatory effects in microglia by activating mGluR4. We employed in
Jing-Jing Zhou et al.
Neuropharmacology, 174, 108159-108159 (2020-05-27)
The hypothalamic paraventricular nucleus (PVN) plays a major role in generating increased sympathetic output in hypertension. Although group III metabotropic glutamate receptors (mGluRs) are expressed in the hypothalamus, little is known about their contribution to regulating PVN presympathetic neurons in
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