SMB00314

Coptisine Chloride

≥98% (HPLC)

• Synonyme(s) : Coptisine chloride, Bis(methylenedioxy)protoberberine chloride, Coptisin Chloride
• Formule empirique (notation de Hill): C₁₉H₁₄ClNO₄
• Numéro CAS: 6020-18-4
• Poids moléculaire : 355.77
• Numéro MDL: MFCD00016676
• Code UNSPSC : 12352205
• ID de substance PubChem : 329824946
• Nomenclature NACRES : NA.25

Propriétés

• Pureté: ≥98% (HPLC)
• Forme: powder
• Application(s): metabolomics; vitamins, nutraceuticals, and natural products
• Température de stockage: −20°C
• Chaîne SMILES: C1(OCO2)=C2C=C(CC[N+]3=C4C=C5C(C(OCO6)=C6C=C5)=C3)C4=C1.[Cl-]
• InChI: 1S/C19H14NO4.ClH/c1-2-16-19(24-10-21-16)14-8-20-4-3-12-6-17-18(23-9-22-17)7-13(12)15(20)5-11(1)14;/h1-2,5-8H,3-4,9-10H2;1H/q+1;/p-1
• Clé InChI: LUXPUVKJHVUJAV-UHFFFAOYSA-M

Description

Description générale

Coptisine chloride is a cytotoxic isoquinoline alkaloid. It is the major bioactive compound of Coptis rhizome, and can also be found in different plants such as Chelidonium majus, Enantia chlorantha. Coptisine is related to berberine and has a similar structure to that of Jatrorrhizine.

Application

Coptisine Chloride has been used to study its binding interactions with single-stranded poly(A) using different absorbance and thermal melting spectroscopic experiments. It may have been used as a standard to analyze Chelidonium majus L. extracted compounds using UV/VIS absorption spectroscopy.

Actions biochimiques/physiologiques

Coptisine Chloride is a potent anti-malarial compound, which also exerts anti-cancer and anti-diabetic properties. It elicits protective effects on gastric mucus membrane and is used as a traditional medicine against gastroenteric diseases. Coptisine chloride also displays anti-microbial activities.It has been analyzed as a cytotoxic agent in hepatoma and leukemic cells and is reported to block cell cycle progression.

Informations sur la sécurité

• Pictogrammes: GHS06
• Mention d'avertissement: Danger
• Mentions de danger: H300 + H330
• Conseils de prudence: P260 - P264 - P271 - P284 - P304 + P340 + P310 - P403 + P233
• Classification des risques: Acute Tox. 2 Inhalation - Acute Tox. 2 Oral
• Code de la classe de stockage: 6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable