SBR00041

Cefiderocol

• Synonyme(s) : S-649266
• Formule empirique (notation de Hill) : C₃₀H₃₄ClN₇O₁₀S₂
• Numéro CAS: 1225208-94-5
• Poids moléculaire : 752.21
• Numéro MDL: MFCD30533432
• Code UNSPSC : 12352111
• Nomenclature NACRES : NA.76

Propriétés

• Essai: ≥95% (HPLC)
• Niveau de qualité: 100
• Forme: solid
• Pertinence de la réaction: reagent type: chelator
• Spectre d'activité de l'antibiotique: Gram-negative bacteria
• Mode d’action: protein synthesis | inhibits
• Température de stockage: −20°C
• Chaîne SMILES: NC1=NC(/C(C(N[C@@H]2C(N3[C@@H]2SCC(C[N+]4(CCCC4)CCNC(C5=CC=C(O)C(O)=C5Cl)=O)=C3C([O-])=O)=O)=O)=N/OC(C(O)=O)(C)C)=CS1
• InChI: 1S/C30H34ClN7O10S2/c1-30(2,28(46)47)48-36-19(16-13-50-29(32)34-16)24(42)35-20-25(43)37-21(27(44)45)14(12-49-26(20)37)11-38(8-3-4-9-38)10-7-33-23(41)15-5-6-17(39)22(40)18(15)31/h5-6,13,20,26H,3-4,7-12H2,1-2H3,(H7-,32,33,34,35,36,39,40,41,42,44,45,46,47)/t20-,26-/m1/s1
• Clé InChI: DBPPRLRVDVJOCL-FQRUVTKNSA-N

Description

Description générale

Cefiderocol has been shown to be effective in preventing the emergence of resistant mutants but is not active against methicillin-resistant Staphylococcus aureus (MRSA) or colistin-resistant bacteria. This versatile compound finds applications in cell biology and biochemical research.

Cefiderocol is a novel injectable siderophore cephalosporin, which was formerly known as S-649266.[1][2] It has a catechol-type siderophore and cephalosporin core and side chains.[1] Cefiderocol has structural similarity with both ceftazidime and cefepime, besides the chlorocatechol group on the end of the C-3 chain.[3]

Application

Cefiderocol has been used:

• study bacterial infections and tracking their uptake in vivo
• the study of the activity of Cefiderocol against gram-negative bacteria[1]

Actions biochimiques/physiologiques

Mode of Action: Cefiderocol binds to specific proteins called penicillin-binding proteins (PBPs) located on the bacterial cell wall. This binding affinity inhibits the synthesis of the bacterial cell wall, leading to cell lysis and bacterial death.

Antimicrobial Spectrum: Cefiderocol has strong antimicrobial properties, especially against a wide spectrum of Gram-negative pathogens.[1][2] Due to its siderophore core it is also a natural iron-chelator, which adds to its antibacterial activities.[1]

Caractéristiques et avantages

• High-quality antibiotic suitable for multiple research applications
• Ideal for Cell Biology and Biochemical research

Autres remarques

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Clause de non-responsabilité

The product is not intended for use as a biocide under global biocide regulations, including but not limited to US EPA′s Federal Insecticide Fungicide and Rodenticide Act, European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR) and others.

Informations sur la sécurité

• Code de la classe de stockage: 11 - Combustible Solids
• Classe de danger pour l'eau (WGK): WGK 3
• Point d'éclair (°F): Not applicable
• Point d'éclair (°C): Not applicable