SAB5702250

Anti-CLDN18.2 Antibody, clone 3J4G7, Rabbit Monoclonal

• Synonyme(s) : CLDN18,SFTA5,SFTPJ
• Code UNSPSC : 12352203
• Nomenclature NACRES : NA.46

Propriétés

• Source biologique: rabbit
• Niveau de qualité: 100
• Matériaux: colorless
• Clone: 3J4G7, monoclonal
• Forme: liquid
• Espèces réactives: human
• Concentration: 1.191 mg/mL
• Technique(s): immunohistochemistry: 1:50 - 1:200
• Couleur: colorless
• Isotype: IgG
• Numéro d'accès UniProt: P56856
• Conditions d'expédition: wet ice
• Température de stockage: −20°C
• Modification post-traductionnelle de la cible: unmodified
• Informations sur le gène: human ... CLDN18.2(51208)

Description

Description générale

This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This gene is upregulated in patients with ulcerative colitis and highly overexpressed in infiltrating ductal adenocarcinomas. PKC/MAPK/AP-1 (protein kinase C/mitogen-activated protein kinase/activator protein-1) dependent pathway regulates the expression of this gene in gastric cells. Alternatively spliced transcript variants encoding different isoforms have been identified.

Immunogène

A synthetic peptide of human CLDN18.2.

PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.

Application

IHC

Informations sur la sécurité

• Pictogrammes: GHS07,GHS09
• Mention d'avertissement: Warning
• Mentions de danger: H317,H411
• Conseils de prudence: P261 - P272 - P273 - P280 - P302 + P352 - P333 + P313
• Classification des risques: Aquatic Chronic 2 - Skin Sens. 1
• Code de la classe de stockage: 10 - Combustible liquids
• Classe de danger pour l'eau (WGK): WGK 3