SAB4301339
Anti-phospho-4E-BP1 (pThr70) antibody produced in rabbit
affinity isolated antibody
Synonyme(s) :
4EBP1, P/OKCL.6, PHAS-I
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100 μL
360.00 CHF
360.00 CHF
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Changer de vue
100 μL
360.00 CHF
About This Item
Code UNSPSC :
12352203
Nomenclature NACRES :
NA.41
360.00 CHF
Check Cart for Availability
Produits recommandés
Source biologique
rabbit
Niveau de qualité
Forme d'anticorps
affinity isolated antibody
Type de produit anticorps
primary antibodies
Clone
polyclonal
Forme
buffered aqueous solution
Poids mol.
12 kDa
Espèces réactives
human
Concentration
1.0 mg/mL
Technique(s)
immunohistochemistry: 1:50-1:100
Isotype
IgG
Numéro d'accès
NP_004086.1.
Numéro d'accès UniProt
Conditions d'expédition
wet ice
Température de stockage
−20°C
Modification post-traductionnelle de la cible
phosphorylation (pThr70)
Informations sur le gène
human ... EIF4EBP1(1978)
Description générale
The gene EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) is localized on human chromosome 8p12. It is a translation repressor that interacts with eukaryotic translation initiation factor 4E (eIF4E).
Spécificité
The antibody detects endogenous levels of 4E-BP1 only when phosphorylated at threonine 70.
Immunogène
Peptide sequence around phosphorylation site of threonine70 (T-K-T(p)-P-P) derived from Human 4E-BP1.
Actions biochimiques/physiologiques
EIF4EBP1 (eukaryotic translation initiation factor 4E binding protein 1) associates with eukaryotic translation initiation factor 4E (eIF4E), which is a multisubunit complex that recruits 40S ribosomal subunits to the 5′ end of mRNA. The interaction of the encoded binding protein with this complex inhibits translation. The phosphorylation of EIF4EBP1 in response to stimuli such as, UV irradiation and insulin signaling, results in dissociation of this factor from the eIF4E complex, leading to initiation of translation of mRNA. This protein participates in cell proliferation, apoptosis, invasion and metastasis. EIF4EBP1 functions as an effector molecule in mTOR (mammalian target of rapamycin complex 1) signaling pathway that regulates protein synthesis. It is found to be overexpressed in hepatocellular carcinoma tissues and serves as a potential prognostic and therapeutic target.
Caractéristiques et avantages
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Forme physique
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Clause de non-responsabilité
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Code de la classe de stockage
10 - Combustible liquids
Classe de danger pour l'eau (WGK)
WGK 1
Point d'éclair (°F)
Not applicable
Point d'éclair (°C)
Not applicable
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EIF4EBP1 overexpression is associated with poor survival and disease progression in patients with hepatocellular carcinoma.
Cha YL, et al.
PLoS ONE, 10(2), e0117493-e0117493 (2015)
High-resolution genomic and expression analyses of copy number alterations in HER2-amplified breast cancer.
Boylan MO, et al.
Breast Cancer Research, 272(28), 17438-17443 (1997)
Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism.
Gingras AC, et al.
Genes & Development, 13(11), 1422-1437 (1999)
eIF4E binding protein 1 expression is associated with clinical survival outcomes in colorectal cancer.
Chao MW, et al.
Oncotarget, 6(27), 24092-24104 (2015)
Hui-Ying Huang et al.
Translational cancer research, 11(5), 1076-1088 (2022-06-17)
New and effective chemotherapy or targeted therapy strategies are needed against laryngeal squamous cell carcinoma (LSCC). We aimed to explore the antitumor effect of dual PI3K/mTOR inhibitor combined with autophagy suppression on LSCC and its underlying mechanism. Hep-2 and AMC-HN-8
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